AdipoUpX™ Human FBN1 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human FBN1 MMLV Particle (Overexpression) is a ready-to-use retroviral vector particle professionally engineered for the stable overexpression of the human FBN1 gene. Fibrillin-1 is the precursor to the glucogenic hormone asprosin, making it a critical focus for studying hunger and glucose regulation. Facilitating stable expression in dividing cells, it allows for in-depth research into hormone secretion and extracellular matrix integrity. All viral particles undergo comprehensive quality control, including titer and mycoplasma testing, ensuring experimental reliability.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: FBN1

Full Name: Fibrillin 1

Gene Symbol: FBN; SGS; WMS; MASS; MFLS; MFS1; OCTD; SSKS; WMS2; ACMICD; ECTOL1; GPHYSD2

Gene ID: 2200

RefSeq ID-1: NP_000129.3

RefSeq ID-2: NM_000138.4

Summary: FBN1 encodes a fibrillin family protein, processed into fibrillin-1 and the hormone asprosin. Fibrillin-1 provides structural support in connective tissues, while asprosin, secreted by white adipose tissue, regulates glucose homeostasis and appetite. Mutations in FBN1 are linked to connective tissue disorders and metabolic dysregulation, making it relevant to obesity and energy balance.

AdipoUpX™ Human FBN1 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

Related Products