AdipoUpX™ Human CASP1 Ad5 Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human CASP1 Ad5 Adenoviral Particle (Overexpression) is engineered for efficient overexpression of the human CASP1 (Caspase-1) gene. It is the executioner of the inflammasome, linking nutrient overload to the inflammatory responses that disrupt glucose metabolism. Every batch undergoes comprehensive QC, including titer and sterility testing, to ensure the reproducibility and safety of your inflammatory signaling studies.

Production Cell Line: HEK293

Viral Backbone: Adenovirus type5 (dE1/E3)

Promoter: CMV

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: All viral preparations have been validated via PCR to confirm the integrity of their vector genomes.

Sterility Test: This product was confirmed to be sterile upon testing.

Mycoplasma Test: This product has passed quality control, confirming that it is free of mycoplasma contamination.

Other QC: We perform customized supplementary testing and in vitro/in vivo transduction assessments based on specific project requirements to analyze the expression levels and biological functions of transgenes.

Storage: Upon receipt of viral preparations, they must be immediately transferred to a -80°C environment for long-term storage.

Stability: The product guarantees excellent stability for 6-12 months when stored continuously at -80°C (and in some cases, up to 2 years). Upon thawing, the working solution is refrigerated at 4°C for up to 2-3 weeks without significant loss of biological activity.

Shipping Condition: Our adenovirus viral products are shipped using dry ice.

Handling Notes: Viral particles are highly sensitive to temperature fluctuations and freeze-thaw cycles. To maintain titer and avoid repeated freeze-thaw cycles, it is recommended to aliquot the vector immediately upon receipt into low-protein-binding tubes and store according to specified conditions. Ensure all operations are performed within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Our company is committed to product quality, and all products have undergone rigorous internal QC inspections. Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application. Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes.

Target Profile

Gene Name: CASP1

Full Name: Caspase 1

Gene Symbol: ICE; P45; IL1BC

Gene ID: 834

RefSeq ID-1: NP_001214.1

RefSeq ID-2: NM_001223.5

Summary: CASP1 encodes caspase-1, a cysteine-aspartic acid protease that functions in both apoptosis and inflammation. Caspase-1 is synthesized as an inactive precursor and undergoes proteolytic processing to form an active enzyme. It was originally identified by its ability to cleave and activate pro–interleukin-1β, a key mediator of inflammation, septic shock, and tissue repair. In obesity, CASP1-driven inflammasome activation contributes to chronic low-grade inflammation and metabolic dysfunction. Multiple alternatively spliced isoforms have been described.

AdipoUpX™ Human CASP1 Ad5 Particle (Overexpression)

Product Overview

Specification

Target Profile

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