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AdipoUpX™ Human CASP1 AAV Particle (Overexpression)
Cat. No.:
V1225XX391
Species:
Human
Target Gene:
CASP1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX391-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX391-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX391-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX391-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX391-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX391-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX391-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX391-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX391-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX391-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human CASP1 AAV Particle (Overexpression) is a ready-to-use gene delivery tool that has undergone rigorous quality control for the stable overexpression of the human CASP1 gene. It is a powerful resource for investigating the inflammasome's role in linking nutrient overload to glucose metabolism disruption. Our AAV platform offers the benefit of high customization, and every batch is fully validated for titer, sterility, and mycoplasma to ensure research reliability and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
CASP1
Full Name:
Caspase 1
Gene Symbol:
ICE; P45; IL1BC
Gene ID:
834
RefSeq ID-1:
NP_001214.1
RefSeq ID-2:
NM_001223.5
Summary:
CASP1 encodes caspase-1, a member of the cysteine-aspartate protease family that plays a dual role in apoptosis and inflammation. Caspase-1 is synthesized as an inactive proenzyme and undergoes proteolytic processing to generate an active heterodimer. It was initially identified by its ability to cleave and activate pro–interleukin-1β, a key inflammatory cytokine involved in immune responses, septic shock, and tissue repair. In obesity, CASP1-driven inflammasome activation contributes to chronic low-grade inflammation and insulin resistance. Alternative splicing produces multiple isoforms.
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