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AdipoUpX™ Human BBS5 AAV Particle (Overexpression)
Cat. No.:
V1225XX247
Species:
Human
Target Gene:
BBS5
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX247-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX247-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX247-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX247-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX247-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX247-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX247-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX247-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX247-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX247-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human BBS5 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that undergoes rigorous QC to ensure stable expression of the human BBS5 gene. Specifically designed for validating BBS5’s role in ciliary localization and receptor trafficking, it serves as a powerful tool for obesity genetics. Our customizable platform allows for the flexible selection of serotypes and fluorescent labels for targeted delivery, supported by comprehensive quality control screening against contaminants.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
BBS5
Full Name:
Bardet-Biedl syndrome 5
Gene ID:
129880
RefSeq ID-1:
NP_689597.1
RefSeq ID-2:
NM_152384.3
Summary:
BBS5 encodes a protein directly implicated in Bardet–Biedl syndrome, a disorder characterized by obesity, retinal dystrophy, polydactyly, renal abnormalities, and cognitive impairment. Experimental evidence from non-human models suggests that BBS5 is expressed in ciliated cells and is required for proper ciliogenesis. Multiple alternatively spliced transcripts have been identified, although their functional differences remain incompletely characterized.
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