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AdipoUpX™ Human ACOX1 AAV Particle (Overexpression)
Cat. No.:
V1225XX314
Species:
Human
Target Gene:
ACOX1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX314-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX314-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX314-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX314-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX314-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX314-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX314-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX314-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX314-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX314-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ACOX1 AAV Particle (Overexpression) is engineered for in vivo functional validation, ensuring the stable overexpression of the human ACOX1 gene. This enzyme is the rate-limiting step in peroxisomal fatty acid oxidation, making this product essential for studying lipid clearance. Clients can freely select cell-specific promoters and reporter genes for precise validation, with quality guaranteed by rigorous purification and comprehensive QC screening.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ACOX1
Full Name:
Acyl-CoA oxidase 1
Gene Symbol:
AOX; ACOX; SCOX; MITCH; PALMCOX
Gene ID:
51
RefSeq ID-1:
NP_001171968.1
RefSeq ID-2:
NM_001185039.2
Summary:
ACOX1 encodes the first and rate-limiting enzyme of peroxisomal fatty acid β-oxidation. The enzyme catalyzes the initial desaturation of acyl-CoAs, facilitating the breakdown of very long-chain fatty acids. Proper ACOX1 function is essential for lipid homeostasis, and its disruption leads to abnormal lipid accumulation.
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