AdipoUpX™ Human ACACB MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ACACB MSCV Particle (Overexpression) is developed for efficient stable expression of the human ACACB gene, which encodes acetyl-CoA carboxylase beta, a key regulator of fatty acid oxidation. ACACB plays an important role in energy balance and obesity-related lipid metabolism. The MSCV vector ensures stable gene integration in hematopoietic stem cells, stem cells, and other mammalian cell systems. Quality assurance includes validated viral titer, sterility testing, and mycoplasma detection.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: ACACB

Full Name: Acetyl-CoA carboxylase beta

Gene Symbol: ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

Gene ID: 32

RefSeq ID-1: NP_001084.3

RefSeq ID-2: NM_001093.4

Summary: ACACB (Acetyl-CoA Carboxylase Beta) encodes an enzyme that controls the rate-limiting step of fatty acid oxidation in the mitochondria. By producing malonyl-CoA, it inhibits the transport of fats into the mitochondria for burning. Unlike its counterpart ACACA, which focuses on fat synthesis, ACACB is a primary regulator of fat "burning" efficiency, making it a significant focus for obesity and metabolic rate research.

AdipoUpX™ Human ACACB MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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