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Trametinib
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Cat. No.:
OB0125LY-094
Size:
5 mg; 10 mg; 50 mg; 100 mg; 200 mg
CAS No.:
871700-17-3
Compound CID:
11707110
Specification
Description:
Trametinib is a MEK inhibitor that inhibits MEK1 and MEK2.
Formula Weight:
615.39
Stability:
3 years in powder form.
Applications:
Trametinib stops the growth of cancer cells by inhibiting the cell signaling pathway (MAPK pathway).
Storage:
Storage at -20°C.
Formula:
C26H23FIN5O4
Appearance:
Solid
Purity:
99.8%
Identity:
Confirmed by NMR and HPLC.
Targets&IC50:
MEK1: 1.8 nM (cell free); MEK2: 0.92 nM (cell free)
Relative Density:
1.743 g/cm3
Library Information
Plate Number:
AOCL-5
Plate Location:
a2
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Autophagy; Apoptosis; MAPK
Targets:
Apoptosis; MEK; Autophagy
Receptors:
Apoptosis; Autophagy; MEK; MEK1; MEK2
DMSO Max Solubility (mg/mL):
7.86 mg/mL
DMSO Max Solubility (mM):
12.77 mM
Ethanol Max Solubility (mg/mL):
1 mg/mL
Saline Max Solubility (mg/mL):
2.1 mg/mL
Saline Max Solubility (mM):
3.41 mM