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Trametinib
Cat. No.:
OB0125LY-094
Appearance:
Solid
Purity:
99.8%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Trametinib is a MEK inhibitor that inhibits MEK1 and MEK2.
Synonym:
871700-17-3; N-[3-[3-Cyclopropyl-5-[ (2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1 (2H)-yl]phenyl]acetamide; N-(3-{3-Cyclopropyl-5-[ (2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1 (2H)-yl}phenyl)acetamide; N-(3-(3-Cyclopropyl-5-( (2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1 (2H)-yl)phenyl)acetamide; N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
CAS No.:
871700-17-3
Compound CID:
11707110
Formula:
C26H23FIN5O4
Formula Weight:
615.39
Specification
Targets & IC50:
MEK1: 1.8 nM (cell free); MEK2: 0.92 nM (cell free)
Relative Density:
1.743 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Trametinib stops the growth of cancer cells by inhibiting the cell signaling pathway (MAPK pathway).
Library Information
Targets:
Apoptosis; MEK; Autophagy
Receptors:
Apoptosis; Autophagy; MEK; MEK1; MEK2
Pathways:
Autophagy; Apoptosis; MAPK
Plate Number:
AOCL-5
Plate Location:
a2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
7.86 mg/mL; 12.77 mM
Ethanol Max Solubility:
1 mg/mL
Saline Max Solubility:
2.1 mg/mL; 3.41 mM
