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Skepinone-L
Cat. No.:
0225LY-0514
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
Skepinone-L is a specialized inhibitor specifically targeting p38 mitogen-activated protein kinase.
Synonym:
CBS3830; 1221485-83-1; (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one; 2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one
CAS No.:
1221485-83-1
Compound CID:
45279963
Formula:
C24H21F2NO4
Formula Weight:
425.42
Specification
Targets&IC50:
p38α: 5 nM
Relative Density:
1.384 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Skepinone-L can be used in intracellular signaling research as a highly selective inhibitor of the p38 alpha MAPK isoform.
Library Information
Target:
p38 MAPK
Receptor:
p38α
Pathways:
Autophagy; MAPK
Plate Number:
AOCL-7
Plate Location:
f7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 117.53 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
79 mg/mL; 185.7 mM
ALogP:
4.729
HBA_Count:
2
HBD_Count:
3
Rotatable Bond:
6
