Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
Samotolisib
Cat. No.:
OB0225LY-0387
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Product Overview
Description:
Samotolisib is a small molecule targeted drug against the PI3K and mTOR pathways with potential anti-tumor activity.
Synonym:
GTPL8918; LY3023414; 1386874-06-1; 8-[5-(2-Hydroxypropan-2-yl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one; (S)-8-(5-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(2-methoxypropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 2H-Imidazo(4,5-C)quinolin-2-one, 1,3-dihydro-8-(5-(1-hydroxy-1-methylethyl)-3-pyridinyl)-1-((2S)-2-methoxypropyl)-3-methyl-
CAS No.:
1386874-06-1
Compound CID:
57519748
Formula:
C23H26N4O3
Formula Weight:
406.48
Specification
Relative Density:
1.239 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Samotolisib can be used in cancer biology research or play an important role in the study of signaling pathways.
Library Information
Targets:
DNA-PK; PI3K/Akt/mTOR pathway
Receptors:
Class I PI3K isoforms; mTOR; mTOR kinase; PI3K
Pathways:
Autophagy; PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-6
Plate Location:
a2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
50 mg/mL; 123.01 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
57 mg/mL; 140.2 mM
ALogP:
1.883
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
5
