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PF-04418948
Cat. No.:
0225LY-1128
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
PF-04418948 is a powerful EP2 receptor antagonist (IC50: 16 nM) with over 2000-fold selectivity against other prostanoid receptors, capable of reversing PGE2-induced tracheal relaxation.
Synonym:
PF 04418948; PF04418948; 1078166-57-0; 1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid; 1-(4-Fluorobenzoyl)-3-(((6-methoxynaphthalen-2-yl)oxy)methyl)azetidine-3-carboxylic acid; I7Z38E70VF; 1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid; 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid; 1-(4-fluorobenzoyl)-3-{[(6-methoxynaphthalen-2-yl)oxy]methyl}azetidine-3-carboxylic acid; 1-(4-fluorobenzoyl)-3-((6-methoxynaphthalen-2-yl)oxymethyl)azetidine-3-carboxylic acid; 1-(4-Fluorobenzoyl)-3-{[(6-methoxy-2-naphthyl)oxy]methyl}azetidine-3-carboxylic acid
CAS No.:
1078166-57-0
Compound CID:
25114442
Formula:
C23H20FNO5
Formula Weight:
409.41
Specification
Targets&IC50:
EP2 receptor: 16 nM
Relative Density:
1.357 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PF-04418948 can be used in receptor biology to study the potent and selective antagonism of the prostaglandin EP2 receptor.
Library Information
Target:
Prostaglandin receptor
Receptor:
PTGERs
Pathways:
GPCR/G protein signaling; Immunology/Inflammation
Plate Number:
AOCL-15
Plate Location:
e4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
45 mg/mL; 109.91 mM
