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Pexmetinib
Cat. No.:
OB0225LY-0430
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR and HPLC.
Size:
Product Overview
Description:
Pexmetinib is an inhibitor that targets MEK and is primarily used to interfere with the MAPK signaling pathway.
Synonym:
ARRY-614; 945614-12-0; 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea; 1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea; N-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)-N'-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea; Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-((5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)phenyl)methyl)-
CAS No.:
945614-12-0
Compound CID:
24765037
Formula:
C31H33FN6O3
Formula Weight:
556.63
Specification
Relative Density:
1.28 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Pexmetinib can be used in the study of tumor cell signaling pathways, especially in tumor cell proliferation.
Library Information
Targets:
Kinases
Receptors:
p38 MAPK; Tie-2
Pathways:
Autophagy; Tyrosine kinase/adaptors; MAPK
Plate Number:
AOCL-6
Plate Location:
e6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
93 mg/mL; 167.1 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
93 mg/mL; 167.1 mM
ALogP:
6.271
HBA_Count:
4
HBD_Count:
3
Rotatable Bond:
9
