Mouse 11 beta hydroxysteroid dehydrogenase type 1 (11beta-HSD1) ELISA kit (1.0-25 ng/mL)

Cat. No.: 0126WXX-365

Assay Type: Quantitative competitive ELISA

Target Species: Mouse

Assay Target: 11-beta-HSD1

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Mouse 11 beta hydroxysteroid dehydrogenase type 1 (11beta-HSD1) ELISA kit (1.0-25 ng/mL)

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Product Overview

Description: Mouse 11 beta hydroxysteroid dehydrogenase type 1 (11beta-HSD1) ELISA kit (1.0-25 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of 11-beta-HSD1 in mouse samples with a range of 1.0-25 ng/mL and a minimum detectable dose (sensitivity) of 0.1 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The ELISA analytical biochemical technique is based on 11-beta-HSD1 antibody-11-beta-HSD1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect 11-beta-HSD1 antigen targets in samples.

Background: 11β-HSD1 is a key redox enzyme localized to the endoplasmic reticulum. It reversibly catalyzes the conversion of cortisol to the inactive metabolite cortisone. Although this enzyme exhibits bidirectional activity in vitro experiments, within living cells, it primarily converts inactive cortisone to active cortisol, thereby increasing local glucocorticoid concentrations. Obesity and type 2 diabetes are associated with abnormalities in glucocorticoid metabolism. The link between 11β-HSD1 and obesity represents a critical and extensively studied area of research.

Synonyms: 11DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; SDR26C1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short chain dehydrogenase/reductase family 26C, member 1; 11-Beta-Hydroxysteroid Dehydrogenase Type 1; EC 1.1.1.146

EC NO.: 1.1.1.146

Applications: Mouse 11 beta hydroxysteroid dehydrogenase type 1 (11beta-HSD1) ELISA kit (1.0-25 ng/mL) is used to quantify 11-beta-HSD1 in serum, plasma, cell culture supernatants, body fluid, and tissue homogenate of mouse, providing data to support research in a wide range of areas, including enzyme & kinase, metabolic pathway, endocrinology, cardiovascular biology, neuro science, hepatology, hormone metabolism, obesity, and others.

Research Area: Enzyme & kinase; Metabolic pathway; Endocrinology; Cardiovascular biology; Neuro science; Hepatology; Hormone metabolism; Obesity

Specification

Sample Type: Serum; Plasma; Cell culture supernatants; Body fluid; Tissue homogenate

Detection Range: 1.0-25 ng/mL

Sensitivity: 0.1 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Recovery: 94-103%

Storage: Store at 2-8°C.

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