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Vitamin B12 test kit

LipoKnoxa™ Human MFN2 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX291
Species: Human
Target Gene: MFN2
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human MFN2 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX291-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-7 AAV3 Lung; Liver; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-8 AAV3 Lung; Liver; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-9 AAV3 Lung; Liver; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-10 AAV4 CNS; Retina; Heart; Lung; Kidney GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-11 AAV4 CNS; Retina; Heart; Lung; Kidney GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-12 AAV4 CNS; Retina; Heart; Lung; Kidney GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCAGGTTTACTGCGAGGAAAT CDS Inquiry
V0126XX291-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCTCAGTGCTTCATCCCATTT 3' UTR Inquiry
V0126XX291-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCACTTTGTCACTGCCAAGAA CDS Inquiry
V0126XX291-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human MFN2 shRNA AAV Particle (Silencing) targets mitofusin 2, which regulates mitochondrial fusion and ER-mitochondria tethering. Suppressing MFN2 via advanced U6 or miR30-based shRNA is vital for investigating mitochondrial dysfunction and its link to insulin resistance. Multiple AAV serotypes are available to optimize delivery, and each batch undergoes rigorous QC verification for functional potency and microbial contaminants to ensure data reliability.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: MFN2
Full Name: Mitofusin 2
Gene Symbol: HSG; MSL; MARF; CMT2A; CPRP1; CMT2A2; HMSN6A; CMT2A2A; CMT2A2B
Gene ID: 9927
RefSeq ID-1: NP_001121132.1
RefSeq ID-2: NM_001127660.2
Summary: MFN2 encodes a GTPase protein embedded in the outer mitochondrial membrane, serving as a master regulator of mitochondrial fusion. This process is vital for maintaining a healthy mitochondrial network and efficient cellular respiration. Beyond its structural role, MFN2 influences vascular smooth muscle cell growth and is increasingly linked to the metabolic dysfunction seen in obesity. While loss-of-function mutations are primarily known to cause Charcot-Marie-Tooth disease (type 2A2), its role in energy homeostasis makes it a critical gene of interest in metabolic research.

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