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Vitamin B12 test kit

LipoKnoxa™ Human HNF4A shRNA AAV Particle (Silencing)

Cat. No.: V0126XX279
Species: Human
Target Gene: HNF4A
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human HNF4A shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX279-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-7 AAV3 Lung; Liver; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-8 AAV3 Lung; Liver; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-9 AAV3 Lung; Liver; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-10 AAV4 CNS; Retina; Heart; Lung; Kidney ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-11 AAV4 CNS; Retina; Heart; Lung; Kidney TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-12 AAV4 CNS; Retina; Heart; Lung; Kidney GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATGACTTGAGGCCTTACTTAA 3' UTR Inquiry
V0126XX279-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TCAGGGTCTGAGCCCTATAAG CDS Inquiry
V0126XX279-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCCTACACCACCCTGGAATTT CDS Inquiry
V0126XX279-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human HNF4A shRNA AAV Particle (Silencing) targets HNF4A, a key transcription factor for hepatic lipid metabolism and pancreatic beta-cell function. By utilizing both U6 and miR30-based shRNA systems, researchers can investigate their role in maturity-onset diabetes of the young (MODY). A broad spectrum of AAV serotypes is provided to ensure optimal hepatic or pancreatic tropism, and every viral preparation is verified via total QC validation.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: HNF4A
Full Name: Hepatocyte nuclear factor 4 alpha
Gene Symbol: TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; TCF-14; HNF4alpha
Gene ID: 3172
RefSeq ID-1: NP_000448.3
RefSeq ID-2: NM_000457.4
Summary: HNF4A encodes a nuclear transcription factor that is essential for the development and functional regulation of the liver, kidneys, and intestines. By binding DNA as a homodimer, it controls a network of other transcription factors that govern nutrient metabolism. Mutations in HNF4A lead to a specific form of monogenic diabetes known as MODY1 (Maturity-Onset Diabetes of the Young). This gene is a key player in the metabolic crosstalk between the gut and the pancreas, and its dysfunction can lead to impaired glucose handling and secondary metabolic complications.

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