Inquiry
Products
Online Inquiry

Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Vitamin B12 test kit

LipoKnoxa™ Human CASP1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX411
Species: Human
Target Gene: CASP1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human CASP1 shRNA AAV Particle (Silencing)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
Fluorescent Reporters:
Titer:
Size:
Add to basket
Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX411-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-7 AAV3 Lung; Liver; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-8 AAV3 Lung; Liver; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-9 AAV3 Lung; Liver; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-10 AAV4 CNS; Retina; Heart; Lung; Kidney CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-11 AAV4 CNS; Retina; Heart; Lung; Kidney CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CACACGTCTTGCTCTCATTAT CDS Inquiry
V0126XX411-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CTACAACTCAATGCAATCTTT CDS Inquiry
V0126XX411-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCAGATATACTACAACTCAAT CDS Inquiry
V0126XX411-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human CASP1 shRNA AAV Particle (Silencing) targets caspase-1, the central enzyme of the inflammasome that processes pro-inflammatory cytokines in obesity. Silencing CASP1 through our dual-strategy shRNA platform (U6 and miR30) helps researchers model chronic metabolic inflammation. Our platform offers multiple AAV serotypes for tissue-specific tropism. Every product is backed by comprehensive QC documentation confirming sequence integrity and microbial safety.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: CASP1
Full Name: Caspase 1
Gene Symbol: ICE; P45; IL1BC
Gene ID: 834
RefSeq ID-1: NP_001214.1
RefSeq ID-2: NM_001223.5
Summary: CASP1 encodes caspase-1, a member of the cysteine-aspartate protease family that plays a dual role in apoptosis and inflammation. Caspase-1 is synthesized as an inactive proenzyme and undergoes proteolytic processing to generate an active heterodimer. It was initially identified by its ability to cleave and activate pro–interleukin-1β, a key inflammatory cytokine involved in immune responses, septic shock, and tissue repair. In obesity, CASP1-driven inflammasome activation contributes to chronic low-grade inflammation and insulin resistance. Alternative splicing produces multiple isoforms.

Related Products

Inquiry
0
Inquiry Basket

Recognizing the multifaceted nature of obesity, we leverage our expertise in preclinical research to provide tailored solutions that address the unique challenges faced by our partners in the biotechnology and pharmaceutical industries.

By Molecule Type

By Products

By Services

Contact Us

Copyright © Protheragen. All rights reserves.