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Vitamin B12 test kit

LipoKnoxa™ Human CARTPT shRNA AAV Particle (Silencing)

Cat. No.: V0126XX261
Species: Human
Target Gene: CARTPT
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human CARTPT shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX261-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-7 AAV3 Lung; Liver; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-8 AAV3 Lung; Liver; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-9 AAV3 Lung; Liver; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-10 AAV4 CNS; Retina; Heart; Lung; Kidney TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-11 AAV4 CNS; Retina; Heart; Lung; Kidney TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TTGATACGTGTGTGAAGTATT 3' UTR Inquiry
V0126XX261-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TTGGCTTAAGCAACAGATAAA 3' UTR Inquiry
V0126XX261-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCTTCCTCCTGAAGTGCTTAT CDS Inquiry
V0126XX261-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human CARTPT shRNA AAV Particle (Silencing) targets the CARTPT, a potent anorexigenic neuropeptide. Silencing CARTPT through our dual-strategy shRNA platform (U6 and miR30) helps researchers model feeding behavior and energy homeostasis. Multiple AAV serotypes are available to optimize delivery to specific hypothalamic nuclei. Each product is backed by comprehensive QC documentation, confirming the total absence of pathogens (sterility and mycoplasma).
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: CARTPT
Full Name: CART prepropeptide
Gene Symbol: CART
Gene ID: 9607
RefSeq ID-1: NP_004282.1
RefSeq ID-2: NM_004291.4
Summary: CARTPT encodes a precursor protein that undergoes proteolytic processing to produce several biologically active neuropeptides. These peptides are involved in central regulation of appetite, energy homeostasis, body weight control, reward-related behaviors, and stress responses. In rodent models, expression of CART-related transcripts is markedly increased following exposure to psychostimulants such as cocaine and amphetamine. Genetic alterations in CARTPT have been linked to increased vulnerability to obesity in human populations.

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