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Vitamin B12 test kit

LipoKnoxa™ Human ACOT11 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX410
Species: Human
Target Gene: ACOT11
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human ACOT11 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX410-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-7 AAV3 Lung; Liver; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-8 AAV3 Lung; Liver; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-9 AAV3 Lung; Liver; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-10 AAV4 CNS; Retina; Heart; Lung; Kidney TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-11 AAV4 CNS; Retina; Heart; Lung; Kidney ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-12 AAV4 CNS; Retina; Heart; Lung; Kidney CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TCTCGGCAAGTGGCTTCTATT CDS Inquiry
V0126XX410-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATCACCAGGGCAACACCTTTG CDS Inquiry
V0126XX410-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CATCGTGAACAATGCCTTCAA CDS Inquiry
V0126XX410-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human ACOT11 shRNA AAV Particle (Silencing) targets ACOT11, a regulator of brown fat thermogenesis and weight gain. Using our dual-strategy platform (U6 and miR30 systems), researchers can evaluate its role in energy expenditure. Multiple AAV serotypes are available for selection. Every batch undergoes total quality control screening for functional titer, sequence integrity, and sterility.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: ACOT11
Full Name: Acyl-CoA thioesterase 11
Gene Symbol: BFIT; THEA; THEM1; STARD14
Gene ID: 26027
RefSeq ID-1: NP_056362.1
RefSeq ID-2: NM_015547.4
Summary: ACOT11 encodes an acyl-CoA thioesterase that converts activated fatty acyl-CoA molecules into free fatty acids and coenzyme A. In mouse models, expression of the ACOT11 homolog in brown adipose tissue is induced by cold exposure and suppressed by warmth, indicating a role in thermogenic regulation. Notably, higher expression levels have been observed in obesity-resistant mice compared with obesity-prone strains, suggesting that ACOT11 may protect against excessive fat accumulation. Multiple transcript variants arise from alternative splicing.

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