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KU-55933
Cat. No.:
0225LY-0518
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
KU-55933 is a selective, ATP-competitive ATM inhibitor (IC50 = 12.9 nM) that promotes apoptosis and exerts antitumor effects.
Synonym:
ATM kinase inhibitor; 587871-26-9; 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one; 2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one; 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
CAS No.:
587871-26-9
Compound CID:
5278396
Formula:
C21H17NO3S2
Formula Weight:
395.49
Specification
Targets&IC50:
ATM: 12.9 nM
Relative Density:
1.419 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
KU-55933 can be used in DNA damage response research to investigate the selective inhibition of ATM kinase.
Library Information
Target:
PI3K; DNA-PK; ATM/ATR; mTOR
Receptor:
ATM/ATR; DNA-PK; mTOR; PI3K
Pathways:
Autophagy; PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-7
Plate Location:
f11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
16.67 mg/mL; 42.15 mM
Ethanol Max Solubility:
19.8 mg/mL; 50.06 mM
