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Icariin
Cat. No.:
0225LY-0506
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Icariin is a natural flavonol glycoside and PPARα activator that inhibits the activity of PDE4 and PDE5 (IC50 = 73.50/432 μM); it is known to enhance bone metabolism, immunity, hematopoiesis, and blood flow in the cerebral and cardiovascular systems.
Synonym:
Ieariline; 489-32-7; 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 3-((6-Deoxymannopyranosyl)oxy)-7-(glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CAS No.:
489-32-7
Compound CID:
5318997
Formula:
C33H40O15
Formula Weight:
676.66
Specification
Targets&IC50:
PDE5: 0.432 μM
Relative Density:
1.55 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Icariin can be used in osteology and reproductive health research, or play an important role in studies of PDE5 inhibition.
Library Information
Target:
PPAR; PDE
Receptor:
PDE5; PPAR
Pathways:
Metabolism; Autophagy; DNA damage/DNA repair
Plate Number:
AOCL-7
Plate Location:
e8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
245 mg/mL; 362.07 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL
