Human very low-density lipoprotein receptor (VLDLR) ELISA kit (3.125-200 ng/mL)

Cat. No.: 0126WXX-2109

Assay Type: Quantitative sandwich ELISA

Target Species: Human

Assay Target: VLDLR

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Human very low-density lipoprotein receptor (VLDLR) ELISA kit (3.125-200 ng/mL)

INQUIRY Datasheet MSDS

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Product Overview

Description: Human very low-density lipoprotein receptor (VLDLR) ELISA kit (3.125-200 ng/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of VLDLR in human samples with a range of 3.125-200 ng/mL and a minimum detectable dose (sensitivity) of 1.875 ng/mL. The kit is highly sensitive and easy to use.

Assay Principle: The microplate provided is pre-coated with an antibody specific to VLDLR. Standards or samples are added to the wells to bind with the capture antibody. Subsequently, a biotinylated detection antibody for VLDLR and an avidin-HRP conjugate are added successively. After washing away free components, a substrate solution is introduced. Wells containing the target will appear blue and then turn yellow upon the addition of a sulphuric acid solution. The O.D. value, measured at 450 nm ± 2 nm, is directly proportional to the VLDLR concentration. Final concentrations are calculated by comparing sample O.D. values to the standard curve.

Background: VLDLR, situated at chromosomal location 9p24, is a multifunctional transmembrane receptor essential for the clathrin-mediated endocytosis of VLDL and the orchestration of Reelin-driven signaling pathways during nervous system development. While its genetic defects are primarily linked to CMARQ1, characterized by cerebellar hypoplasia and developmental delays, its metabolic role is critical for lipid transport and systemic cholesterol homeostasis.

Synonyms: VLDL-R

Applications: Human very low-density lipoprotein receptor (VLDLR) ELISA kit (3.125-200 ng/mL) is used to quantify VLDLR in serum, plasma, and biological fluids of humans, providing data to support research in a wide range of areas, including signal transduction, metabolic pathway, endocrinology, cardiovascular biology, hepatology, obesity, and others.

Research Area: Signal transduction; Metabolic pathway; Endocrinology; Cardiovascular biology; Hepatology; Obesity

Specification

Sample Type: Serum; Plasma; Biological fluids

Detection Range: 3.125-200 ng/mL

Sensitivity: 1.875 ng/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Recovery: 87-106%

Storage: Store at 2-8°C.

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