Human insulin like growth factor binding protein 2 (IGFBP-2) ELISA kit (10 pg/mL)

Cat. No.: 0126WXX-471

Assay Type: Quantitative ELISA

Target Species: Human

Assay Target: IGFBP-2

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Human insulin like growth factor binding protein 2 (IGFBP-2) ELISA kit (10 pg/mL)

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Product Overview

Description: Human insulin like growth factor binding protein 2 (IGFBP-2) ELISA kit (10 pg/mL) is an ELISA-based in vitro research tool designed specifically for the quantitative detection of IGFBP-2 in human samples with a minimum detectable dose (sensitivity) of 10 pg/mL. The kit is highly sensitive and easy to use.

Assay Principle: This assay employs a specific antibody for human IGFBP-2 coated on a 96-well plate. Standards and samples are pipetted into the wells, where IGFBP-2 is captured by the immobilized antibody. After washing, a biotinylated anti-human IGFBP-2 antibody is added. Following the removal of unbound biotinylated antibody, HRP-conjugated streptavidin is introduced. After a final wash, TMB substrate is added, and color develops in proportion to the amount of bound IGFBP-2. The stop solution shifts the color from blue to yellow, and the intensity is measured at 450 nm.

Background: IGFBP-2 is a multifunctional molecule that plays a crucial role in human growth, metabolism, and cellular processes by regulating the biological activity of insulin-like growth factors (IGFs). Primarily through binding to IGF proteins, IGFBP-2 prolongs their half-life in the body and modulates their interactions with cell surface receptors, thereby inhibiting or enhancing the pro-growth effects of IGFs. The role of IGFBP-2 in obesity has garnered increasing attention. Its reduced levels are closely associated with obesity, dyslipidemia, and insulin resistance.

Synonyms: IBP-2; IGF-binding protein 2; IGFBP2; BP2, IBP2; Insulin-Like Growth Factor Binding Protein 2, 36kDa; Insulin-Like Growth Factor-Binding Protein 2

Applications: Human insulin like growth factor binding protein 2 (IGFBP-2) ELISA kit (10 pg/mL) is used to quantify IGFBP-2 in cell culture supernatants, serum, plasma, and urine of humans, providing data to support research in a wide range of areas, including immunity, endocrinology, signal transduction, obesity, and others.

Research Area: Immunity; Endocrinology; Signal transduction; Obesity

Specification

Sample Type: Cell culture supernatants; Serum; Plasma; Urine

Sensitivity: 10 pg/mL

Cross-reactivity: No significant cross-reactivity or interference was observed.

Storage: Store at -20°C.

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