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AS-252424
Cat. No.:
0225LY-1485
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
AS-252424 displays 10-fold selectivity for PI3Kγ (IC50: 33 nM) compared to the alpha isoform.
Synonym:
900515-16-4; AS252424; AS 252424; (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; (5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione; (5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (5Z)-5-{[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; 2,4-Thiazolidinedione, 5-((5-(4-fluoro-2-hydroxyphenyl)-2-furanyl)methylene)-, (5Z)-
CAS No.:
900515-16-4
Compound CID:
11630874
Formula:
C14H8FNO4S
Formula Weight:
305.28
Specification
Targets&IC50:
PI3Kγ: 33 nM
Relative Density:
1.559 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AS-252424 can be used in signaling pathway research to explore the potent and selective inhibition of PI3K gamma.
Library Information
Target:
PI3K; Casein kinase
Receptor:
CK2; PI3Kα; PI3Kγ
Pathways:
Metabolism; Stem cell regulation; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-20
Plate Location:
a8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
47.5 mg/mL; 155.59 mM
ALogP:
3.11
HBA_Count:
3
HBD_Count:
2
Rotatable Bond:
2
