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MLN8054
Cat. No.:
0225LY-0665
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
MLN8054 serves as a selective and powerful Aurora A kinase inhibitor, demonstrating an IC50 of 4 nM.
Synonym:
869363-13-3; 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid; 4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzoic acid; 4-(9-chloro-7-(2,6-difluorophenyl)-5H-benzo[e]pyrimido[5,4-c]azepin-2-ylamino)benzoic acid; Benzoic acid, 4-((9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido(5,4-d)(2)benzazepin-2-yl)amino)-; 4-((9-chloro-7-(2,6-difluorophenyl)-5h-pyrimido(5,4-d)(2)benzazepin-2-yl)amino)benzoic acid
CAS No.:
869363-13-3
Compound CID:
11712649
Formula:
C25H15ClF2N4O2
Formula Weight:
476.86
Specification
Targets&IC50:
Aurora A: 4 nM
Relative Density:
1.48 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
MLN8054 can be used in mitotic research to explore the selective inhibition of the Aurora A kinase.
Library Information
Target:
PKA; Src; Casein kinase; Aurora kinase
Receptor:
Aurora A; Aurora B; CK2; Lck; PKA
Pathways:
Metabolism; Tyrosine kinase/adaptors; Cell cycle/Checkpoint; Angiogenesis; Chromatin/Epigenetic; Stem cell regulation
Plate Number:
AOCL-9
Plate Location:
f2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
31.25 mg/mL; 65.53 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
