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AdipoUpX™ Human WNT10B AAV Particle (Overexpression)
Cat. No.:
V1225XX400
Species:
Human
Target Gene:
WNT10B
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX400-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX400-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX400-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX400-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX400-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX400-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX400-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX400-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX400-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX400-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human WNT10B AAV Particle (Overexpression) is engineered for stable functional validation, achieving efficient expression of the human WNT10B gene. As a potent inhibitor of adipogenesis, it is a key asset for investigating anti-obesity signaling pathways and progenitor cell fate. Clients can select from various AAV serotypes and cell-specific promoters for precise targeted delivery. Comprehensive quality control is performed on all viral particle products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
WNT10B
Full Name:
Wnt family member 10B
Gene Symbol:
SHFM6; STHAG8; WNT-12
Gene ID:
7480
RefSeq ID-1:
NP_003385.2
RefSeq ID-2:
NM_003394.3
Summary:
WNT10B encodes a secreted signaling molecule of the WNT family that regulates cell fate determination and embryonic patterning. WNT10B signaling inhibits adipocyte differentiation and acts as a molecular switch governing adipogenesis. Dysregulation of this pathway can alter adipose tissue development and contribute to obesity. The protein shares high amino acid identity with mouse Wnt10b and is clustered with WNT1 on chromosome 12q13.
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