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AdipoUpX™ Human MAGEL2 AAV Particle (Overexpression)
Cat. No.:
V1225XX248
Species:
Human
Target Gene:
MAGEL2
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX248-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX248-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX248-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX248-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX248-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX248-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX248-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX248-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX248-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX248-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human MAGEL2 AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human MAGEL2 gene, a key factor in Prader-Willi syndrome. This makes it an ideal tool for studying hypothalamic dysfunction and the regulation of satiety. Our platform offers highly customizable services, allowing clients to freely select cell-specific promoters and reporter genes for precise validation, with guaranteed safety through rigorous titer and sterility detection.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
MAGEL2
Full Name:
MAGE family member L2
Gene Symbol:
PWLS; nM15; NDNL1; SHFYNG
Gene ID:
54551
RefSeq ID-1:
NP_061939.3
RefSeq ID-2:
NM_019066.5
Summary:
MAGEL2 is a paternally expressed, imprinted gene located within the Prader–Willi syndrome (PWS) critical region on chromosome 15q11–q13. PWS is characterized by neonatal hypotonia, developmental delay, hyperphagia, and early-onset obesity. MAGEL2 shares structural similarity with necdin (NDN), a neuronal differentiation factor implicated in PWS pathogenesis, suggesting that MAGEL2 contributes to hypothalamic dysfunction underlying the obesity phenotype.
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