Product Overview
Description:
AdipoUpX™ Human CRP Ad5 Adenoviral Particle (Overexpression) utilizes a highly efficient promoter for the overexpression of the human CRP gene. As a classic marker of systemic inflammation, this tool allows researchers to study the direct effects of C-reactive protein on vascular health and metabolic signaling. It enables functional validation of CRP’s role as a bridge between chronic low-grade inflammation and cardiovascular risk in obesity.
Production Cell Line:
HEK293
Viral Backbone:
Adenovirus type5 (dE1/E3)
Promoter:
CMV
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
All viral preparations have been validated via PCR to confirm the integrity of their vector genomes.
Sterility Test:
This product was confirmed to be sterile upon testing.
Mycoplasma Test:
This product has passed quality control, confirming that it is free of mycoplasma contamination.
Other QC:
We perform customized supplementary testing and in vitro/in vivo transduction assessments based on specific project requirements to analyze the expression levels and biological functions of transgenes.
Storage:
Upon receipt of viral preparations, they must be immediately transferred to a -80°C environment for long-term storage.
Stability:
The product guarantees excellent stability for 6-12 months when stored continuously at -80°C (and in some cases, up to 2 years). Upon thawing, the working solution is refrigerated at 4°C for up to 2-3 weeks without significant loss of biological activity.
Shipping Condition:
Our adenovirus viral products are shipped using dry ice.
Handling Notes:
Viral particles are highly sensitive to temperature fluctuations and freeze-thaw cycles. To maintain titer and avoid repeated freeze-thaw cycles, it is recommended to aliquot the vector immediately upon receipt into low-protein-binding tubes and store according to specified conditions. Ensure all operations are performed within a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Our company is committed to product quality, and all products have undergone rigorous internal QC inspections. Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application. Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes.
Target Profile
Gene Name:
CRP
Full Name:
C-reactive protein
Gene Symbol:
PTX1
Summary:
CRP encodes C-reactive protein, a member of the pentraxin family involved in innate immunity and inflammatory regulation. Pentraxins participate in complement activation and modulation through interactions with pattern recognition molecules and complement regulators. CRP contains a calcium-dependent ligand-binding domain with a characteristic flattened beta-jellyroll structure and circulates primarily as a pentamer, while monomeric forms are found in tissues. CRP recognizes pathogens and damaged host cells and promotes their clearance via humoral and cellular effector mechanisms. Circulating CRP levels rise markedly during acute-phase responses to infection, injury, or inflammation, and persistently elevated CRP levels have been associated with chronic low-grade inflammation and adult-onset obesity.
