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Timosaponin AIII
Cat. No.:
0225LY-0618
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Timosaponin AIII induces ER stress and inhibits mTORC1, leading to autophagy followed by apoptosis in HeLa cells (IC50: 10 uM); while it induces autophagy in both normal and malignant cells, its pro-apoptotic effects are tumor-selective.
Synonym:
Filiferin B; AneMarsaponin A3; Timosaponin A3; 41059-79-4; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; [(25S)-5ss-Spirostan-3ss-yl]2-O-(ss-D-glucopyranosyl)-ss-D-galactopyranoside; (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-((1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro(5-oxapentacyclo(10.8.0.02,9.04,8.013,18)icosane-6,2'-oxane)-16-yl)oxyoxan-3-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
CAS No.:
41059-79-4
Compound CID:
15953793
Formula:
C39H64O13
Formula Weight:
740.92
Specification
Targets&IC50:
mTORC1(MDAMB231): 6 μM; mTORC1(BT474 cells): 2.5 μM
Relative Density:
1.366 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Timosaponin AIII can be used in cell biology research to study the induction of autophagy and apoptosis in cancer cells.
Library Information
Target:
mTOR; AChE
Receptor:
AChE; mTORC1
Pathways:
Neuronal signaling; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-9
Plate Location:
a4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 337.42 mM
ALogP:
1.39
HBA_Count:
6
HBD_Count:
7
Rotatable Bond:
6
