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Negletein
Cat. No.:
0225LY-0774
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Negletein is a multifunctional compound with antimicrobial and anti-inflammatory activities that activates Nrf2 and inhibits the NFAT transcription factor; it also acts as a neuroprotectant by enhancing nerve growth factor and preventing amyloid beta 42 oligomerization.
Synonym:
7-O-Methylbaicalein; Baicalein-7-methylether; 29550-13-8; 5,6-Dihydroxy-7-methoxyflavone; 5,6-Dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 5,6-dihydroxy-7-methoxy-2-phenyl-; 5,6-dihydroxy-7-methoxy-2-phenylchromen-4-one
CAS No.:
29550-13-8
Compound CID:
471719
Formula:
C16H12O5
Formula Weight:
284.26
Specification
Targets&IC50:
TNF-α: 16.4 nM (IC50); IL-1β: 10.8 nM (IC50)
Relative Density:
1.42 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Negletein can be used in antioxidant research to examine the protective effects of natural flavonoids against oxidative cellular damage.
Library Information
Target:
NOS; IL receptor; TNF receptor
Receptor:
Receptor iNOS; IL-1R; TNFR1/2; IL-1β; TNF-α
Pathways:
Immunology/Inflammation; Apoptosis
Plate Number:
AOCL-11
Plate Location:
a3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 175.9 mM
Solubility:
Soluble in chloroform, dichloromethane, ethyl acetate, acetone, etc.
