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ML-7 hydrochloride
Cat. No.:
0225LY-1076
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
ML-7 hydrochloride is a specific, reversible, and cell-permeable ATP-competitive inhibitor of myosin light chain kinase (Ki: 300 nM) that also displays inhibitory activity against PKC and PKA.
Synonym:
ML-7 HCl; 110448-33-4; 1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride; ML-7 HCl; ML 7 hydrochloride; 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride; ML-7 (hydrochloride); 1-(5-iodonaphthalen-1-ylsulfonyl)-1,4-diazepane hydrochloride; 1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane;hydrochloride; Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride; 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4 -diazepine, Hydrochloride
CAS No.:
110448-33-4
Compound CID:
9803932
Formula:
C15H18ClIN2O2S
Formula Weight:
452.74
Specification
Targets&IC50:
PKC: 42 μM; PKA: 21 μM; MLCK: 0.3 μM(Ki)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ML-7 hydrochloride can be used in smooth muscle research to investigate the selective inhibition of myosin light chain kinase (MLCK).
Library Information
Target:
PKC; PKA; YAP; Myosin; Serine/threonin kinase
Receptor:
MLCK; Myosin; PKA; PKC; YAP
Pathways:
Chromatin/Epigenetic; Cytoskeletal signaling; Stem cell regulation; Cell cycle/Checkpoint; Metabolism; Tyrosine kinase/adaptors
Plate Number:
AOCL-14
Plate Location:
g11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
46 mg/mL; 101.6 mM
