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LipoKnoxa™ Human MC3R shRNA Ad5 Particle (Silencing)
Cat. No.:
V0126XX17
Species:
Human
Target Gene:
MC3R
Vector System:
Adenovirus
Modulation Type:
Silencing (shRNA)
SPECIFIC INQUIRY
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| Sub Cat. No. | TargetSeq | Region | Inquiry |
|---|---|---|---|
| V0126XX17-1 | GACCTTCGAGGACCAGTTTAT | CDS | Inquiry |
| V0126XX17-2 | GTTCAGCCAACACTGCCTAAT | CDS | Inquiry |
| V0126XX17-3 | CCAGCACATGGACAACATCTT | CDS | Inquiry |
| V0126XX17-4 | Other | Inquiry |
Product Overview
Description:
LipoKnoxa™ Human MC3R shRNA Ad5 Particle (Silencing) focuses on the MC3R, which plays a distinct role in regulating energy rheostat and feed efficiency. This silencing tool allows for the differentiation of MC3R and MC4R functions in weight regulation. Our customizable platform includes flexible reporter gene inclusion and maintains strict QC oversight, including titer validation and sterility checks, to ensure consistent performance in vivo and in vitro.
Production Cell Line:
HEK293
Viral Backbone:
Adenovirus type 5 (dE1/E3)
Promoter:
U6; CMV; EF1α; CAG; UBC
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
All viral preparations are validated via Sequencing and PCR to ensure 100% sequence identity and the structural integrity of the vector genomes.
Sterility Test:
This product has been certified sterile following comprehensive microbial growth analysis, confirming the absence of bacterial and fungal contamination.
Mycoplasma Test:
This product was certified negative for mycoplasma contamination following stringent QC analysis, ensuring the absence of all mycoplasmal agents.
Other QC:
Beyond standard protocols, we offer customized knockdown efficiency validation through in vitro and in vivo assessments. This includes precise analysis of mRNA/protein reduction and subsequent biological responses to ensure the functional potency of the shRNA-mediated gene silencing.
Storage:
Upon receipt, viral preparations should be immediately transferred to -80°C for long-term storage to ensure maximum stability and maintain product integrity.
Stability:
This product maintains excellent biological activity for 6–12 months (and up to 2 years in specific cases) when stored continuously at -80°C. Once thawed, the working solution remains stable for 2–3 weeks at 4°C without significant loss of viral potency.
Shipping Condition:
All viral preparations are shipped on dry ice to ensure maximum biological activity and stability during transit.
Handling Notes:
Viral particles are susceptible to temperature fluctuations and freeze-thaw cycles. To preserve functional titers, it is essential to aliquot the vector into low-protein-binding tubes immediately upon first thaw. To ensure experimental success and biological safety, all procedures must be conducted within a certified biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
While our products are committed to excellence through rigorous internal QC inspections, we cannot guarantee specific performance or experimental outcomes due to the inherent complexity of biological systems. Users assume full responsibility for product storage, handling, and strict compliance with all applicable safety protocols, biosafety requirements, and legal regulations during all operational processes.
Target Profile
Gene Name:
MC3R
Full Name:
Melanocortin 3 receptor
Gene Symbol:
MC3; OB20; OQTL; BMIQ9; MC3-R
Gene ID:
4159
RefSeq ID-1:
NP_063941.3
RefSeq ID-2:
NM_019888.3
Summary:
MC3R is a G-protein-coupled receptor (GPCR) that acts as a key component of the melanocortin system, responding to peptides like MSH and ACTH. Unlike the MC4R, the MC3R is expressed outside the traditional neuroendocrine tissues, suggesting broader regulatory roles. Its function in energy homeostasis is highlighted by genetic models: mice lacking MC3R exhibit increased adiposity (fat mass) even with reduced food intake. Consequently, MC3R variants are implicated in human susceptibility to obesity and are studied as potential targets for appetite and energy balance modulation.
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