LipoKnoxa™ Human FABP1 shRNA Ad5 Particle (Silencing)

Cat. No.: V0126XX176

Species: Human

Target Gene: FABP1

Vector System: Adenovirus

Modulation Type: Silencing (shRNA)

LipoKnoxa™ Human FABP1 shRNA Ad5 Particle (Silencing)

INQUIRY Datasheet MSDS

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX176-1	GTGACAATAAACTGGTGACAA	CDS	Inquiry
V0126XX176-2	CAAGTCTGTGACCGAACTCAA	CDS	Inquiry
V0126XX176-3	GTGTCGGAAATCGTGCAGAAT	CDS	Inquiry
V0126XX176-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human FABP1 shRNA Ad5 Particle (Silencing) enables the targeted knockdown of liver fatty acid-binding protein, which mediates the uptake and intracellular trafficking of long-chain fatty acids in hepatocytes. Utilizing a robust RNAi framework, this tool allows for the investigation of hepatic lipid partitioning and fatty acid oxidation rates. Every batch undergoes comprehensive QC, including functional titer and sterility testing, providing a secure and high-performing gene-silencing solution for metabolic genomic research.

Production Cell Line: HEK293

Viral Backbone: Adenovirus type 5 (dE1/E3)

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: All viral preparations are validated via Sequencing and PCR to ensure 100% sequence identity and the structural integrity of the vector genomes.

Sterility Test: This product has been certified sterile following comprehensive microbial growth analysis, confirming the absence of bacterial and fungal contamination.

Mycoplasma Test: This product was certified negative for mycoplasma contamination following stringent QC analysis, ensuring the absence of all mycoplasmal agents.

Other QC: Beyond standard protocols, we offer customized knockdown efficiency validation through in vitro and in vivo assessments. This includes precise analysis of mRNA/protein reduction and subsequent biological responses to ensure the functional potency of the shRNA-mediated gene silencing.

Storage: Upon receipt, viral preparations should be immediately transferred to -80°C for long-term storage to ensure maximum stability and maintain product integrity.

Stability: This product maintains excellent biological activity for 6–12 months (and up to 2 years in specific cases) when stored continuously at -80°C. Once thawed, the working solution remains stable for 2–3 weeks at 4°C without significant loss of viral potency.

Shipping Condition: All viral preparations are shipped on dry ice to ensure maximum biological activity and stability during transit.

Handling Notes: Viral particles are susceptible to temperature fluctuations and freeze-thaw cycles. To preserve functional titers, it is essential to aliquot the vector into low-protein-binding tubes immediately upon first thaw. To ensure experimental success and biological safety, all procedures must be conducted within a certified biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: While our products are committed to excellence through rigorous internal QC inspections, we cannot guarantee specific performance or experimental outcomes due to the inherent complexity of biological systems. Users assume full responsibility for product storage, handling, and strict compliance with all applicable safety protocols, biosafety requirements, and legal regulations during all operational processes.

Target Profile

Gene Name: FABP1

Full Name: Fatty acid binding protein 1

Gene Symbol: FABPL; L-FABP

Gene ID: 2168

RefSeq ID-1: NP_001434.1

RefSeq ID-2: NM_001443.3

Summary: FABP1 encodes a liver-expressed fatty acid–binding protein that facilitates the intracellular transport and metabolism of long-chain fatty acids and bile acids. By regulating hepatic lipid uptake and storage, FABP1 influences systemic lipid homeostasis and susceptibility to obesity-related metabolic disturbances.

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