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(E/Z)-Elafibranor
Cat. No.:
0225LY-0891
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
(E/Z)-Elafibranor functions as a dual agonist for the PPARα and PPARδ receptors, demonstrating EC50 values of 45 nM and 175 nM, respectively.
Synonym:
(E/Z)-GFT505; 824932-88-9; Elafibranor; 923978-27-2; (E/Z)-Elafibranor; GFT 505; 2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid; (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid; 2-{2,6-dimethyl-4-[(1E)-3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl]phenoxy}-2-methylpropanoic acid; 2-(2,6-Dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid; 2-[2,6-dimethyl-4-[(~{E})-3-(4-methylsulfanylphenyl)-3-oxidanylidene-prop-1-enyl]phenoxy]-2-methyl-propanoic acid; Propanoic acid, 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propen-1-yl)phenoxy)-2-methyl-
CAS No.:
824932-88-9
Compound CID:
9864881
Formula:
C22H24O4S
Formula Weight:
384.49
Specification
Targets&IC50:
PPARδ: 175 nM(EC50); PPARα: 45 nM(EC50)
Relative Density:
1.21 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
(E/Z)-Elafibranor can be used in pharmacological assays to evaluate the mixture of isomers in PPAR alpha/delta dual activation.
Library Information
Target:
PPAR
Receptor:
PPARα; PPARδ
Pathways:
Metabolism; DNA damage/DNA repair
Plate Number:
AOCL-12
Plate Location:
d10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 156.05 mM
