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AdipoUpX™ Human SIM1 AAV Particle (Overexpression)
Cat. No.:
V1225XX204
Species:
Human
Target Gene:
SIM1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX204-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX204-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX204-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX204-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX204-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX204-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX204-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX204-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX204-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX204-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human SIM1 AAV Particle (Overexpression) is engineered for in vitro and in vivo functional validation, achieving stable expression of the human SIM1 gene. As a critical transcription factor for hypothalamic development, it is an ideal tool for studying the neural circuits governing appetite suppression and satiety. Clients can flexibly select AAV serotypes and fluorescent reporter genes for precise targeted delivery. Comprehensive quality control, including titer and mycoplasma testing, is performed on all products to ensure high-fidelity metabolic research.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
SIM1
Full Name:
SIM bHLH transcription factor 1
Gene Symbol:
bHLHe14
Gene ID:
6492
RefSeq ID-1:
NP_001361698.1
RefSeq ID-2:
NM_001374769.1
Summary:
SIM1 is a homolog of the Drosophila single-minded gene and is primarily expressed during development, with notable detection in fetal tissues. Given the established role of the sim gene in neurogenesis in Drosophila, SIM1 has been implicated in human brain development and hypothalamic function. Dysregulation of SIM1 is associated with abnormalities in neurodevelopment and energy homeostasis, and mutations have been linked to severe obesity, likely through impaired appetite and body weight regulation pathways.
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