AdipoUpX™ Human IRX3 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IRX3 MMLV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human IRX3 gene. This transcription factor is a major downstream effector of FTO-linked obesity, regulating the switch between white and beige adipocytes. Genome integration enables the establishment of stable cell lines for researching thermogenic pathways. All viral particle products undergo comprehensive quality control to ensure safety and efficacy in obesity genetics research.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: IRX3

Full Name: Iroquois homeobox 3

Gene Symbol: IRX-1; IRXB1

Gene ID: 79191

RefSeq ID-1: NP_077312.2

RefSeq ID-2: NM_024336.3

Summary: IRX3 is a member of the Iroquois homeobox gene family, primarily known for its role in directing early neural development and vertebrate embryo patterning. More recently, IRX3 has been identified as a critical metabolic regulator that determines the energy-storage identity of adipocyte progenitors. It influences whether energy is stored as white fat or dissipated as heat in brown fat.

AdipoUpX™ Human IRX3 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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