AdipoUpX™ Human FOXO1 Ad5 Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human FOXO1 Ad5 Adenoviral Particle (Overexpression) is engineered for efficient overexpression of the human FOXO1 gene. This transcription factor is a major downstream target of insulin signaling, regulating gluconeogenesis and adipogenesis. This product serves as a powerful gene delivery tool for investigating the molecular basis of insulin resistance. Our customizable platform ensures safety through rigorous QC, including titer, sterility, and mycoplasma testing.

Production Cell Line: HEK293

Viral Backbone: Adenovirus type5 (dE1/E3)

Promoter: CMV

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: All viral preparations have been validated via PCR to confirm the integrity of their vector genomes.

Sterility Test: This product was confirmed to be sterile upon testing.

Mycoplasma Test: This product has passed quality control, confirming that it is free of mycoplasma contamination.

Other QC: We perform customized supplementary testing and in vitro/in vivo transduction assessments based on specific project requirements to analyze the expression levels and biological functions of transgenes.

Storage: Upon receipt of viral preparations, they must be immediately transferred to a -80°C environment for long-term storage.

Stability: The product guarantees excellent stability for 6-12 months when stored continuously at -80°C (and in some cases, up to 2 years). Upon thawing, the working solution is refrigerated at 4°C for up to 2-3 weeks without significant loss of biological activity.

Shipping Condition: Our adenovirus viral products are shipped using dry ice.

Handling Notes: Viral particles are highly sensitive to temperature fluctuations and freeze-thaw cycles. To maintain titer and avoid repeated freeze-thaw cycles, it is recommended to aliquot the vector immediately upon receipt into low-protein-binding tubes and store according to specified conditions. Ensure all operations are performed within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Our company is committed to product quality, and all products have undergone rigorous internal QC inspections. Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application. Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes.

Target Profile

Gene Name: FOXO1

Full Name: Forkhead box O1

Gene Symbol: FKH1; FKHR; FOXO1A

Gene ID: 2308

RefSeq ID-1: NP_002006.2

RefSeq ID-2: NM_002015.3

Summary: FOXO1 is a pivotal transcription factor that acts as a "metabolic architect." It sits at the crossroads of insulin signaling; when insulin is low, FOXO1 enters the nucleus to promote glucose production and inhibit adipogenesis. In obesity, the failure of insulin to properly exclude FOXO1 from the nucleus leads to hyperglycemia and impaired fat-cell maturation.

AdipoUpX™ Human FOXO1 Ad5 Particle (Overexpression)

Product Overview

Specification

Target Profile

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