AdipoUpX™ Human ARL13B Ad5 Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ARL13B Ad5 Adenoviral Particle (Overexpression) utilizes a highly efficient promoter for the overexpression of the human ARL13B gene. It is a regulatory GTPase essential for cilia structure and signaling; defects in ciliary trafficking are a major cause of genetic obesity. This product enables researchers to validate its role in ciliary-mediated metabolic sensing. Our customizable platform ensures safety through rigorous QC, including mycoplasma and sterility detection.

Production Cell Line: HEK293

Viral Backbone: Adenovirus type5 (dE1/E3)

Promoter: CMV

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: All viral preparations have been validated via PCR to confirm the integrity of their vector genomes.

Sterility Test: This product was confirmed to be sterile upon testing.

Mycoplasma Test: This product has passed quality control, confirming that it is free of mycoplasma contamination.

Other QC: We perform customized supplementary testing and in vitro/in vivo transduction assessments based on specific project requirements to analyze the expression levels and biological functions of transgenes.

Storage: Upon receipt of viral preparations, they must be immediately transferred to a -80°C environment for long-term storage.

Stability: The product guarantees excellent stability for 6-12 months when stored continuously at -80°C (and in some cases, up to 2 years). Upon thawing, the working solution is refrigerated at 4°C for up to 2-3 weeks without significant loss of biological activity.

Shipping Condition: Our adenovirus viral products are shipped using dry ice.

Handling Notes: Viral particles are highly sensitive to temperature fluctuations and freeze-thaw cycles. To maintain titer and avoid repeated freeze-thaw cycles, it is recommended to aliquot the vector immediately upon receipt into low-protein-binding tubes and store according to specified conditions. Ensure all operations are performed within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Our company is committed to product quality, and all products have undergone rigorous internal QC inspections. Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application. Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes.

Target Profile

Gene Name: ARL13B

Full Name: ARF like GTPase 13B

Gene Symbol: JBTS8; ARL2L1

Gene ID: 200894

RefSeq ID-1: NP_001167621.1

RefSeq ID-2: NM_001174150.2

Summary: ARL13B is a small GTPase localized within the primary cilium, where it is required for ciliary assembly and maintenance. Since the cilium acts as the cell's antenna for sensing metabolic hormones, defects in ARL13B lead to Joubert syndrome, illustrating how structural defects in the cell can result in systemic metabolic and neurological dysfunction.

AdipoUpX™ Human ARL13B Ad5 Particle (Overexpression)

Product Overview

Specification

Target Profile

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