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AdipoUpX™ Human ACLY AAV Particle (Overexpression)
Cat. No.:
V1225XX382
Species:
Human
Target Gene:
ACLY
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX382-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX382-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX382-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX382-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX382-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX382-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX382-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX382-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX382-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX382-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ACLY AAV Particle (Overexpression) is a high-titer, ready-to-use AAV product and ensures the efficient and stable expression of the human ACLY gene through an optimized promoter. This product is specifically designed to facilitate research into the primary engine of lipid construction, supporting studies on fatty acid and cholesterol synthesis. All viral products undergo rigorous internal quality control to ensure reliability for metabolic research. Our customizable platform also allows for the flexible selection of fluorescent labels for precise targeted delivery and multifunctional tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ACLY
Full Name:
ATP citrate lyase
Gene Symbol:
ACL; ATPCL; CLATP
Gene ID:
47
RefSeq ID-1:
NP_001087.2
RefSeq ID-2:
NM_001096.2
Summary:
ACLY encodes ATP citrate lyase, a cytosolic enzyme that generates acetyl-CoA from citrate and coenzyme A through an ATP-dependent reaction. The enzyme functions as a tetramer composed of four similar subunits and produces acetyl-CoA and oxaloacetate while hydrolyzing ATP to ADP and phosphate. Acetyl-CoA derived from ACLY serves as a key precursor for lipid and cholesterol biosynthesis, pathways that are frequently upregulated in obesity and metabolic syndrome. Increased ACLY activity supports de novo lipogenesis in adipose tissue and liver, contributing to fat accumulation. In neuronal tissues, ACLY may also participate in acetylcholine synthesis. Multiple transcript variants encoding distinct isoforms have been described.
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