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A-3 hydrochloride
Cat. No.:
0225LY-1078
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
A-3 hydrochloride serves as a non-selective, cell-permeable antagonist of various kinases, including PKA (Ki: 4.3 μM), MLCK (Ki: 7.4 μM), and PKC (Ki: 47 μM).
Synonym:
78957-85-4; A3 hydrochloride; A-3 (hydrochloride); N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride; N-(2-Aminoethyl)-5-chloronaphthalene-1-sulphonamide hydrochloride; A3 HCl
CAS No.:
78957-85-4
Compound CID:
9861903
Formula:
C12H14Cl2N2O2S
Formula Weight:
321.22
Specification
Targets&IC50:
CK2: 5.1 μM （ki）; CK1: 80 μM （ki）; PKC: 47 μM （ki）; PKA: 4.3 μM （ki）
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
A-3 hydrochloride can be used in kinase research to study the potent inhibition of PKA and other cyclic nucleotide-dependent kinases.
Library Information
Target:
CaMK; PKC; PKA; Casein kinase
Receptor:
CaMK; CK1; CK2; PKA; PKC
Pathways:
Metabolism; Cytoskeletal signaling; Chromatin/Epigenetic; Stem cell regulation; Tyrosine kinase/adaptors; Neuronal signaling
Plate Number:
AOCL-14
Plate Location:
h3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
125 mg/mL; 389.14 mM
