Obesity Models
InquiryOverview of Obesity Models
Obesity has become an increasingly serious health problem worldwide. Protheragen focuses on providing cutting-edge obesity model services to the scientific research community, especially Preclinical Studies of Anti-Obesity Therapeutics, a key link in the development of anti-obesity drugs.
Our obesity models services not only cover comprehensive solutions from in vivo animal models to in vitro cell models but also place special emphasis on customization and efficiency. Through carefully designed obesity models, we help clients simulate the complex pathological process of human obesity and provide a solid experimental basis for the screening of anti-obesity drugs, research on mechanism of action, and efficacy evaluation.
We leverage both in vivo and in vitro obesity models to rigorously assess the efficacy of our Anti-Obesity Therapy Development. In vivo models, such as rodent and primate systems, allow us to observe the holistic impact of our treatments, including Anti-Obesity Small Molecule Drug Development, Anti-Obesity Gene Therapy Development, and Anti-Obesity Tissue Engineering Therapy Development. These models provide insights into drug absorption, distribution, metabolism, and excretion (ADME), as well as potential side effects. In vitro models, utilizing adipose tissue cultures and cell lines, enable us to delve into the molecular mechanisms of our therapies, including Anti-Obesity Cell Therapy Development, Anti-Obesity Antibody Therapy Development, and cutting-edge Anti-Obesity Nanotherapy Development.
Revolutionizing Obesity Research with In Vivo Models: Accurate, Reliable, and Innovative Solutions for Understanding and Combating Obesity
We provide a highly customized in vivo obesity model to meet the needs of obesity research. These models not only simulate the various pathological characteristics of human obesity but also ensure the accuracy and reliability of research results through sophisticated induction and evaluation processes.
In Vivo Obesity Models for Obesity Research
We offer in vivo obesity models for obesity research through four approaches: by methods, by genes, by factors, and by taxonomy, providing a diverse range of models tailored to meet specific research needs and insights into obesity mechanisms.
By Methods
We specialize in providing comprehensive in vivo obesity models for obesity research, encompassing a suite of services including gene editing-based, hypothalamic injury-based, oophorectomy-based, and drug injection-based model development. Each service is tailored to address unique research requirements, offering precision and depth in exploring obesity pathways.
- Gene Editing-based In Vivo Obesity Model Development Service
- Hypothalamic Injury-based In Vivo Obesity Model Development Service
- Oophorectomy-based In Vivo Obesity Model Development Service
- Drug Injection-based In Vivo Obesity Model Development Service
By Genes
We offer a comprehensive range of in vivo obesity models for obesity research, including custom single gene mutation, single gene editing, multi-gene mutation, transgenic, and chromosome replacement model services. Each service is tailored to meet specific research needs, enabling precise exploration of obesity mechanisms through genetically modified models.
By Factors
We offer a versatile range of in vivo obesity models for obesity research, including high fat-induced, high sugar-induced, protein-induced, other nutrient-induced, and chemical-induced obesity models. These models cater to diverse research needs, enabling precise insights into the mechanisms underlying obesity.
- High Fat-induced Obesity Model
- High Sugar-induced Obesity Model
- Protein-induced Obesity Model
- Other Nutrient-induced Obesity Model
- Chemical-induced Obesity Model
By Taxonomy
We provide a comprehensive suite of in vivo obesity models for obesity research, encompassing mammal obesity models and non-mammal obesity models. Our diverse range of models cater to various research needs, enabling precise insights into obesity mechanisms across different species.
- Dog Obesity Model
- Pig Obesity Model
- Mouse Obesity Model
- Rat Obesity Model
- Monkey Obesity Model
- Guinea Pig Obesity Model
- Rabbit Obesity Model
Non-mammal Obesity Model
- Customized Model Construction
Animal species selection: Depending on the research purpose, we provide a variety of animal species, such as mice, rats, and rabbits. Each animal has its own unique physiological characteristics and application scenarios.
Diet-induced model: We induce obesity in animals by designing specific high-fat, high-sugar, or high-energy diets.
Genetic and gene editing models: We use gene editing technology to construct obesity animal models with specific gene mutations to study the relationship between genes and obesity deeply.
- Obesity Phenotype Assessment
Weight and body fat monitoring: We regularly measure the weight, body fat percentage, and body fat distribution of animals, and use non-invasive or minimally invasive techniques to reduce animal pain.
Metabolic parameter detection: These parameters include the detection of key metabolic indicators such as blood sugar, insulin, blood lipids, and leptin to comprehensively evaluate the impact of obesity on the animal metabolic system.
Behavioral observation: We record the activity level, feeding behavior, and energy consumption of animals to explore the impact of obesity on behavioral patterns.
Empower Obesity Research with In Vitro Cell Models: Precision, Insight, and Innovative Solutions for Healthier Futures
We also provide in vitro cell models, which also emphasize customization and efficiency.
In Vitro Cell Models for Obesity Research
We offer a wide array of in vitro cell models for obesity research. These models provide a robust platform for studying obesity mechanisms and its associated metabolic disorders.
- Cell Line Selection and Customization
Adipocyte cell lines: We provide a variety of adipocyte cell lines such as 3T3-L1 preadipocytes. We also provide adipocyte cell lines from different sources such as rats and mice.
Other metabolic-related cells: We provide other metabolic-related cell lines such as hepatocytes and pancreatic islet cells for studying the effects of obesity on systemic metabolism.
- Cell Model Induction and Treatment
High-fat treatment: We add fatty acids or liposomes of specific concentrations and types to the cell culture medium to simulate the effects of the high-fat environment on cells in the body.
Drug and hormone treatment: According to research needs, we add anti-obesity drugs, hormones, or cytokines such as insulin and leptin to the cells to observe cell responses.
- Cell Function Evaluation
Lipid metabolism evaluation: We use methods such as triglyceride content determination to evaluate intracellular lipid accumulation and metabolism.
Gene and protein expression analysis: We use real-time polymerase chain reaction (qPCR), western blot, and other technologies to detect the expression levels of obesity-related genes and proteins.
Signal pathway research: We use flow cytometry, immunofluorescence, and other methods to study the activation and inhibition of obesity-related signal pathways.
Workflow
We streamline our workflow by first conducting demand analysis to understand clients' research objectives, model types, and customized needs. Following this, we formulate a detailed plan for model construction and evaluation. We then proceed with model building through animal breeding, cell culture, and gene editing to create obesity models. After rigorous phenotypic and functional verification, we collect and analyze data to form comprehensive research reports, ultimately delivering results to clients with continued technical support and consulting services.
Applications of Obesity Models
- Exploring the pathogenesis of obesity: Obesity models help researchers simulate and deeply explore the biological processes and molecular mechanisms of obesity, such as adipocyte differentiation and energy metabolism imbalance.
- Evaluating the efficacy of anti-obesity drugs: Obesity models can be used to test newly developed anti-obesity drugs, evaluate their weight loss effects, and provide key data for drug development.
- Studying obesity-related complications: Obesity models can be used to study how obesity leads to the occurrence and development of complications such as diabetes and provide new strategies for the prevention and treatment of these diseases.
Advantages
- Highly simulate human physiological and pathological characteristics: Our obesity models are carefully designed and optimized to highly simulate the physiological and pathological changes of human obesity.
- Advanced gene editing technology: We use advanced gene editing technology to precisely edit obesity-related genes and create obesity models with specific genetic backgrounds.
- Comprehensive phenotypic evaluation system: We establish a comprehensive phenotypic evaluation system to continuously monitor and evaluate multiple indicators of obesity models, such as weight, body fat percentage, metabolic rate, insulin sensitivity, and inflammatory factor levels.
Publication
Published: 2016
Journal: Disease Models & Mechanisms
IF: 4.3
Results: The authors discuss various preclinical models used in obesity research, highlighting their significance in understanding the pathology and developing potential treatments. They explore the use of rodent models, particularly genetically modified mice, and diet-induced obesity models, to investigate the genetic, molecular, and environmental factors contributing to obesity. Additionally, they address the limitations of these models and emphasize the need for improved and more predictive systems to better mimic human obesity and its associated metabolic disorders.
Fig.1 Computerised food-intake monitoring from a binge-like eating study. (Barrett, et al., 2016)
Frequently Asked Questions
How do I choose the right obesity model for my research?
Choosing the right obesity model depends on your specific research goals and hypotheses. We recommend that you first clarify the purpose of your research and consider the type of obesity (e.g., genetic, environmental), related complications (e.g., diabetes, cardiovascular disease), and the required experimental period and cost. Our technical support team provides personalized advice based on your needs to help you choose the most suitable model.
What technical support and services do you provide?
We provide a full range of technical support and services, including:
- Model consultation: Provide model selection suggestions based on your research needs.
- Model ordering and delivery: Ensure that the model is delivered to your laboratory safely and on time.
- Feeding and management guidance: Provide detailed feeding and management manuals to ensure that the model remains in optimal condition during the experiment.
- Experimental design and data analysis: Assist in designing experimental plans and provide data analysis support.
- Customized services: Provide customized model development services based on client needs.
Protheragen is committed to providing clients with professional and customized obesity models to help researchers make more breakthroughs in the field of obesity and related metabolic diseases. Please feel free to contact us for more details if you are interested in our obesity models!
Reference
- Barrett, P.; et al. Preclinical models for obesity research. Disease models & mechanisms. 2016, 9(11): 1245-1255.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.