Anti-Obesity Therapy Development
InquiryOverview
Obesity alters the metabolic state of the body and significantly increases the risk of many diseases such as diabetes and cardiovascular disease. Anti-obesity therapies are one of the research hotspots. Based on the in-depth exploration of the pathogenesis of obesity and the integration of multidisciplinary efforts (chemistry, pharmacology, biotechnology, and materials), several emerging anti-obesity strategies are being proposed and intensively researched. Protheragen provides an anti-obesity therapy development service and offers different therapeutic options to clients.
Pursuing Innovative Excellence: Ultra-Comprehensive Anti-Obesity Therapy Development Service
Our experienced researchers are at the forefront of obesity research and offer flexible and innovative solutions to assist our clients in their anti-obesity therapeutic research. Specific development processes include the following:
Screening of Targets
The therapeutic mechanisms of anti-obesity therapies include promoting the conversion of white adipose tissue (WAT) to increase energy expenditure, acting on the gastrointestinal tract to inhibit fat absorption, acting on neural pathways to suppress appetite, etc. Targets include various Receptors, Metabolic Regulators, Signaling Molecules, Enzymes, etc.
Design of Anti-Obesity Therapy
After identifying the target of the action, it is necessary to design and optimize the corresponding anti-obesity therapy.
Anti-Obesity Small Molecule Drug Development
Anti-obesity drug therapy is an adjunctive treatment in the management of obesity. Anti-obesity drugs have been developed for a variety of targets. Natural products such as plant extracts, polyphenols, and terpenoids are also found to exert some anti-obesity effects by inhibiting inflammation and oxidative stress, reducing adipocyte formation, and increasing lipolysis and energy expenditure. We screen or develop natural products or other small molecule drugs that regulate appetite, energy homeostasis, etc. Their mechanism of action, therapeutic potential, and toxicological effects on obesity are evaluated.
Computer simulations play an important role in screening and analyzing the binding affinity and drug-like properties of anti-obesity drugs. We also provide Computer-aided Anti-obesity Drug Discovery Services including the following:
Anti-Obesity Gene Therapy Development
Gene therapy has shown promising results in combating insulin resistance and treating obesity. We offer a wide range of anti-obesity gene therapy development services targeting specific targets. The obesity-related genes are delivered to cells or animal models or regulated, and the role of these strategies is evaluated in glucose metabolism, energy balance, obesity reversal, etc. We have a variety of gene editing technologies, including viral and non-viral-based transduction and genome editing technologies, which enable precise regulation of genes.
Anti-Obesity Cell Therapy Development
Cell therapy is a hot topic in research related to the treatment of obesity. Based on advanced gene editing technologies, we provide an end-to-end anti-obesity cell therapy development service, from protocol design, and preclinical optimization to data analysis. We modify various cells (stem cells, CAR-T cells, etc.) and transplant them into animal models. The therapeutic efficacy and safety of cell therapies are evaluated by analyzing changes in histology, lipid metabolism, gene expression, and others. Specific cell therapies available include the following:
- Stem Cell Therapy Development
- CAR-T Cell Therapy Development
- Other Therapy Development
Anti-Obesity Antibody Therapy Development
Antibody therapy is an innovative strategy with better specificity. We provide a one-stop service from anti-obesity antibody screening, and antibody optimisation to preclinical studies. After screening the lead antibody by phage display, hybridoma technology, and other techniques, the antibody is further optimized. Afterward, we produce antibodies using various stable cell lines. Subsequent preclinical validation is performed.
Anti-Obesity Tissue Engineering Therapy Development
Anti-obesity tissue engineering therapy involves the screening of targets related to adipose tissue function and energy metabolism, the design of therapies, and preclinical studies. We develop biocompatible scaffolds and biomaterials for tissue engineering by combining various disciplines such as regenerative medicine and biotechnology. Sustained weight loss effects are exerted by delivering anti-obesity drugs, promoting fat metabolism, tissue repair, etc.
Anti-Obesity Nanotherapy Development
Anti-obesity nanotherapy is being investigated as an alternative strategy to treat obesity. It has various advantages over conventional therapies such as fewer side effects, higher tolerability, and higher efficacy. We develop nanotechnology-based weight loss strategies targeting WAT, adipose brown tissue, and others. Various nanocarriers are used to selectively deliver drugs to specific receptors, dramatically improving drug utilization and biosafety.
Preclinical Studies of Anti-Obesity Therapies
- Obesity Models
We have a variety of In Vivo (Mouse, Rat, Zebrafish, Rabbit, etc.) and In Vitro Models (3T3-L1 Preadipocytes, Brown Adipose Cells, etc.) for anti-obesity therapeutic studies. These models are reliable tools for studying the genetic mechanism of obesity, obesity-related gene function, and evaluation of anti-obesity therapies. - Comprehensive assessment of anti-obesity therapies
We conduct relevant cell-based anti-obesity functional analyses and animal model-based evaluation of anti-obesity therapies. Behavioral, phenotypic characteristics, physiological and pathological changes, biomarker detection, gene expression analysis, etc., are examined. Pharmacodynamic, pharmacokinetic, safety, and biological analyses of the therapies allow us to optimize the therapies.
Workflow
Applications
- Diabetes therapy research: Anti-obesity therapies have the potential to treat diabetes by exerting some antidiabetic effects, including through metabolic modulation.
- Cancer therapy research: Targeted anti-obesity therapy may also be a potential cancer treatment strategy.
- Combination therapy strategy research: Gene therapy, cell therapy, etc., are paired with other therapeutic strategies, such as diet and behavior, to improve the effectiveness of treatment.
Advantages
- We endeavor to be a trusted partner for anti-obesity therapy development needs, always putting the client at the center, pursuing innovative excellence, and striving to deliver results beyond expectations.
- We offer a customized anti-obesity therapy development service and personalized support to meet diverse needs.
- A wealth of obesity models provides reliable support for research on different types of obesity and anti-obesity therapies targeting different targets.
Other Personalized Services
We are at the forefront of obesity research and treatment development and are committed to translating new scientific discoveries into effective means of combating obesity. We offer a comprehensive range of obesity-related tests and analyses that delve into the complexities of obesity and its complications. Diagnostic tests and obesity prediction services provide reliable data to support the development of obesity interventions. We also provide precise gene editing services to support our clients' obesity research in various ways. In addition, we also perform obesity biomarker, microbiome, and pathobiology testing, which has revealed the molecular mechanisms of obesity. Our team also helps to design professional weight management and weight loss programs.
Publication Data
Technology: Isothermal rolling circle technique
Journal: Pharmaceutics
IF: 5.4
Published: 2022
Results: This paper describes the application of various biomaterials in treating obesity and its complications. Biomaterials have good potential for application by extending the half-life of anti-obesity drugs, improving drug stability, and increasing site-specific drug enrichment while reducing adverse effects. Obesity treatment strategies based on biomaterials include chitosan and other biomaterials with anti-obesity activity to combat obesity, coupling small molecule drugs to polymers to increase their stability, regulating the release rate, and physically encapsulating drugs for targeted delivery. The development of biomaterials has helped in the research of anti-obesity therapies.
Fig.1 Poly (citric acid)-glycerol-polylysine /miR33 agonists for the treatment of obesity. (Li, et al., 2022)
Frequently Asked Questions
What is the cost of developing a specific anti-obesity therapy through your services?
The cost of developing an anti-obesity therapy may vary depending on the type of study required, and the complexity of the experiment. We communicate with our clients before the project to develop a complete experimental plan that fits their timeline and budget.
How long does the anti-obesity therapy development typically take?
The development time for anti-obesity therapies varies depending on the therapeutic strategy and specific experimental requirements. Specific experimental requirements, development scale, etc., may all affect the overall development time. We provide detailed trial protocols and timelines during the communication phase of the project and adjust them to meet the client's research needs with maximum efficiency.
Protheragen offers a cutting-edge anti-obesity therapeutic development service based on deep expertise and extensive technical capabilities. Please feel free to contact us to learn more about the details of your anti-obesity therapy. We will be sure to help you make decisions on all key aspects of your research.
Reference
- Li, J.; et al. Biomaterial-based therapeutic strategies for obesity and its comorbidities. Pharmaceutics. 2022, 14(7): 1445.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.