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Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.

Food/Water Intake Assessment

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Overview

Obesity is caused by an imbalance between energy input (i.e., food intake) and energy output. Successful obesity therapeutics target both homeostatic and nonhomeostatic mechanisms. In terms of food/water intake assessment, Protheragen has a professional team that employs precise experimental methods to evaluate the pharmacodynamic effects of various obesity therapies through careful observation and data analysis of Obesity Models. Our highly trained and talented team provides you with a one-stop shop for preclinical studies of anti-obesity therapeutics to meet our clients' needs.

Explore with Us the Pharmacodynamic Impact of Food/Water Intake

  • Obesity Animal Models-Food/Water Intake

    Our company has developed and constructed a series of animal models such as the high-fat diet (HFD) and diet-induced obesity (DIO) for use in the pharmacodynamic study. Our evaluation system not only focuses on short-term changes in food and water intake but also seeks to explore the sustained effects of long-term and how these effects interact with homeostatic and non-homeostatic mechanisms in the brain.

    In our in-depth studies, we have found that small changes in food and water intake significantly affect weight regulation. Therefore, Protheragen has introduced a high-precision monitoring system to track the experimental animals in real time for 24 hours to ensure the accuracy and reliability of the data.

    We have noted that social behavior and environmental influences may also play a role in appetite regulation, and have therefore included consideration of psychological and behavioral factors in the assessment model, to more fully simulate the actual effect.

    Through advanced techniques and state-of-the-art equipment, our team offers services to analyze the complex relationships between energy metabolism and consumption patterns. Moreover, we offer fasting metabolic profiling to further understanding of the physiological responses to fasting, which provides valuable insights into the adaptive mechanisms of organisms under different dietary conditions.

    Flowchart of diet-induced obesity modeling. (Protheragen)

  • In Vitro Simulation

    Drug-food interactions may significantly affect the safety and efficacy of anti-obesity drugs. Drug-food co-administration may affect drug absorption and systemic exposure, causing alterations in drug safety and efficacy. Our company offers strategies to assess the effects of food on physiological parameters in the gastrointestinal tract of animals. Through in vitro simulation experiments, our researchers accurately explore how food components affect drug metabolic pathways, thus providing a scientific basis for the rational clinical use of drugs.

    Schematic of in vitro simulation analysis. (Protheragen)

Workflow

Our professional pharmacodynamics experts provide clients with efficient food/water intake assessment services. The workflow includes consultation, experimental design, pre-test preparation, drug treatment, observation recording, pharmacodynamic analysis, safety assessment, and data reporting. During the experiment, drug treatments are given and data are recorded, including food/water intake, body weight, and physiological indicators. Through statistical analysis of the data, our researchers assess the effects and mechanisms of action of the drugs, as well as conduct safety assessments.

Applications

  • Food/water intake assessment can be used to elaborate the effect of food on physiological parameters of the gastrointestinal tract of animals.
  • Food/water intake assessment can be used to control the bioavailability of drugs and the safety of drug dosage.
  • Food/water intake assessment can be used for the study of obesity mechanisms and the development of new therapies.

Advantages of Us

  • Whether it is in vitro organ simulation or in vivo animal model development, our experienced research team provides you with the most satisfactory solutions to facilitate the development of your anti-obesity project.
  • Based on reliable technology and a well-trained team, we provide our clients with personalized solutions ranging from custom model design, and pharmacodynamic studies to data visualization.
  • Our company is equipped with a continuous monitoring system to keep an eye on the animals' food and water.
Our Services

With advanced analytical tools and a reliable research team, we offer efficient anti-obesity research services. We provide an in-depth analysis of hereditary obesity from a genetic perspective. Through biomarker development and obesity prediction to reveal the mechanism of personalized obesity. Moreover, our company provides microbiology and pathology studies in association with obesity. Our goal is to explore the mechanisms of obesity from multiple perspectives and refine data of our clients.

Publication Data

Technology: Hematoxylin and eosin staining, Quantification, RNA extraction

Journal: BMC Pharmacology and Toxicology

Published: 2020

Results: In this study, the researchers constantly checked the body weight and food intake of the mice. The effects of silibinin on adipose inflammation, fat accumulation, hepatic lipogenesis, and glucose homeostasis were assessed by biochemical, histological, and gene expression analyses. Silibinin-treated mice showed significant reductions in body weight and fat mass. This means that silibinin effectively intervenes in diet-induced obesity. Some complications associated with obesity, such as abnormalities in glucose-lipid metabolism, also improved after treatment with silibinin. This study demonstrates the potential application of silibinin as a natural compound for the treatment of obesity and its complications.

Fig.1 Silibinin treatment suppressed adipose tissue hypertrophy. Fig.1 Comparison of factors in the treatment and control groups. (Alsaggar, et al., 2020)

Frequently Asked Questions

How are animal model experiments grouped?

To ensure that scientifically valid data can be obtained, special attention should be paid to the establishment of control groups when experimental animals are grouped. The control group can be divided into a control group and a parallel control group. Moreover, We also set up a dose-control group to see if there is a dose dependency.

What are the considerations for efficiently constructing DIO?

First, it must be clarified whether it is a simple obesity model. Our staff strictly controls the feeding density and optimizes the feeding method. Reduce human intervention, such as gavage, blood collection, injection, and other experimental operations, which to a certain extent has an impact on the physiological state of experimental animals.

Protheragen provides high-quality food/water intake assessment to promote the pharmacodynamic study of anti-obesity therapeutics. We utilize a state-of-the-art automated monitoring system to track animal intake and activity in real-time, as well as sophisticated sensors to monitor body weight changes. We aim to provide our clients with accurate experimental data to facilitate the pharmacodynamic study. No matter what you need, please feel free to contact us to provide you with the most satisfactory solution!

Reference

  1. Alsaggar, M.; et al. Silibinin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model in mice. BMC Pharmacology and Toxicology. 2020, 21: 1-8.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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