Overview

Adipose tissue and body fat are not only an energy reservoir but are also deeply involved in key biological functions such as metabolic regulation, inflammatory response, and endocrine regulation. In health assessments such as cardiovascular disease and diabetes, it is crucial to directly and quantitatively analyze the content and distribution of abdominal fat. Therefore, accurate identification and quantification of adipose tissue and its functional properties are significant in gaining insight into disease mechanisms. Protheragen provides comprehensive preclinical studies of anti-obesity therapeutics to clients worldwide.

Our company understands the importance of preclinical research. We utilize cutting-edge animal modeling techniques and highly sophisticated analytical tools to explore the specific effects of anti-obesity therapeutics on body fat and its distribution.

Accurate Quantification of Body Fat Distribution Leads to Anti-Obesity Therapy Development

Protheragen provides high-quality body fat quantification and distribution studies by imaging technology. Our data analysis team compiles and analyzes all monitoring data to ensure that it is delivered to the client at the earliest opportunity.

• Bioelectrical Impedance Analysis (BIA)

  Our company provides a specialized BIA service for the measurement of body fat. Since different tissues (e.g. fat, muscle, bone) have their unique conductivity properties, the BIA equipment derives the percentage of body fat of an individual based on these measurements.

• Magnetic Resonance Imaging (MRI)

  MRI and magnetic resonance spectroscopy (MRS) are currently considered the most comprehensive tools for body fat quantification in organisms. Our researchers use high spectral resolution proton spectroscopy to characterize the unsaturation, polyunsaturation index, and average chain length of body fat molecules in vivo. In particular, the MRS technique provides information on the metabolism of adipose tissue.

• Dual-Energy X-Ray Absorptiometers (DXA)

  Our company uses DXA to analyze detailed measurements of fat distribution and bone density in various parts of the body. The density analysis we provide includes but is not limited to, body bone, fat, and lean tissue.

• Computed Tomography (CT)

  Body fat has a different X-ray attenuation compared to other soft tissues and therefore has a distinct density in micro-CT images. We rely on our advanced technology to provide professional density analysis and data visualization services to our clients. We have specialized software to process and segment images to enhance contrast. Our data analysts provide clients with volumetric reconstruction of different organs including fat.

Workflow

Our company attaches great importance to the pharmacodynamic study of anti-obesity therapeutics and is committed to exploring and optimizing therapeutic options through a rigorous and systematic workflow. We focus on the construction and continuous optimization of animal models that meet the pathophysiological characteristics of obesity. We strive for models that accurately reflect the physiological responses to anti-obesity therapeutic interventions and provide a reliable basis for drug efficacy assessment. We systematically evaluate the mechanism of action and effects of anti-obesity therapeutics on weight management and metabolic regulation to ensure the comprehensiveness and accuracy of the data.

Applications

• Quantitative analysis of body fat distribution plays an important role in the evaluation of anti-obesity therapies, visualizing the efficacy of new therapies by comparing body fat distribution and content before and after the efficacy of the drug.
• Quantitative analysis of body fat distribution can be used to explore disease pathogenesis and therapeutic targets.
• Quantitative analysis of body fat distribution plays a key role in the prevention of obesity, hypertension, diabetes, atherosclerosis hyperlipidemia, etc.

Advantages of Us

• Our service team has expertise in several subject areas such as pharmacology, zoology, imaging, and more. We are committed to meeting all of our client's needs for scientific research.
• Our animal models meet various research needs. Our researchers are constantly optimizing the stability and reliability of the models, which helps to simulate pathologies more accurately.
• Our dedicated data processing team visualizes the effects of different anti-obesity therapies on body fat distribution to help clients understand the mechanism of action.
• Our company offers a quantification service that allows for quantification in the whole animal as well as localization and measurement in selected organs/regions of the body.

Learn More about Our Obesity Research

Based on years of experience in obesity-related health risk assessment, as well as excellence in research quality, methodological innovation, and client satisfaction, our company is committed to providing comprehensive obesity impact assessment and health improvement solutions to leading and emerging nutrition and health research organizations, healthcare institutions, and research teams.

Our Services

Publication Data

Frequently Asked Questions

What are the quantitative principles and advantages of MRI?

MRI utilizes different magnetic resonance properties to measure the amount of hydrogen protons in different components of a sample. Due to the different chemical environments of the hydrogen protons in fat and water, they exhibit different signals on the nuclear magnetic resonance (NMR) spectra. MRI detects the distribution of body fat in several parts of the body, including subcutaneous fat, visceral fat, and fat in skeletal muscle. Interestingly, MRI distinguishes between white and brown adipose tissue.

Is adipose tissue the same as body fat?

In body composition analysis, adipose tissue is conceptually different from body fat. According to the five-level classification, grade IV adipose tissue is loose connective tissue containing adipocytes, water, interstitial cells, and blood vessels. Grade II body fat refers to the total mass of lipids such as triglycerides in the body. It is not limited to adipocytes, but also distributed in the intermuscular and interstitial tissues and inside the cells, such as hepatocytes and cell membranes.

Through our advanced bioanalytical technology and data visualization team, Protheragen provides our clients with advanced body fat distribution and quantification services. Our specialized pharmacology research team constructs animal models according to the client's needs. Welcome to contact us for consultation.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Energy Expenditure Monitoring
• Food/Water Intake Assessment
• Measurement of Ectopic Fat Accumulation
• Molecular Biomarker Analysis