Overview of In Vivo Obesity Models for Obesity Research

Obesity is a pervasive global health issue, contributing to a range of severe medical conditions such as diabetes, cardiovascular diseases, and certain cancers. Understanding the underlying mechanisms and developing effective treatments requires robust and reliable model systems that mimic human obesity accurately. At Protheragen, we are committed to advancing obesity research by providing comprehensive and high-quality in vivo obesity models for anti-obesity therapeutic studies.

Our Preclinical Studies of Anti-Obesity Therapeutics including Obesity Models are designed to meet the rigorous demands of scientific research. With cutting-edge technology and a team of skilled scientists, we offer customized in vivo obesity models that cater to a wide spectrum of research needs.

We utilize in vivo obesity models to rigorously assess the effectiveness of our Anti-Obesity Therapy Development programs. These models, typically rodent systems that exhibit physiological and metabolic characteristics similar to human obesity, serve as critical tools for evaluating our Anti-Obesity Small Molecule Drug Development and other potential treatments. This in vivo approach is integral to our drug development pipeline, ensuring that our anti-obesity therapy development efforts are grounded in robust, physiologically relevant data.

In Vivo Obesity Models: The Cornerstone of Future-Focused Obesity Therapeutics and Prevention

• Model Construction Strategies

  Genetic modification model: We use gene editing technology to knock out, knock-in, or mutate specific genes in experimental animals to simulate genetic variations related to human obesity.

  Dietary-induced model: We induce obese phenotypes in experimental animals by giving them a high-calorie and high-fat diet for a long time to simulate obesity caused by bad eating habits.

  Hormone-induced model: We give specific hormones (such as insulin and growth hormone releasing peptide) by injection or implantation to affect energy metabolism balance and cause obesity.

  Combined model: We combine the above methods to build a more complex in vivo model that is close to the pathophysiological state of human obesity.

• Operation Steps

  Model design: We design a suitable obesity model construction plan based on client needs and research purposes, including selecting suitable experimental animals, determining gene editing sites, or diet formulas.

  Model construction: We perform experimental operations according to the design plan, including gene editing, feeding management, and data collection.

  Model validation: We validate the biological characteristics of the constructed obesity model, including the measurement of indicators such as body weight, body fat ratio, metabolic rate, and histopathological examination to confirm whether the model successfully simulates the pathophysiological state of human obesity.

Workflow

We start by conducting a thorough demand analysis and designing personalized solution plans tailored to our client's research objectives. Following this, we meticulously prepare experimental materials and animals as stipulated in our plan. Then, we proceed with model construction through precise gene editing and feeding management. After constructing the model, we verify and evaluate its biological characteristics to mimic human obesity accurately. Post-experimentation, we organize the data and compile a comprehensive report detailing the process, results, and recommendations. Lastly, we offer ongoing services, including model maintenance and data analysis, to empower our clients in their continued obesity research endeavors.

Applications of In Vivo Obesity Models

• Drug screening and evaluation: The in vivo obesity model can be used to test potential anti-obesity drugs and evaluate their efficacy, safety, and mechanism of action.
• Disease mechanism research: The in vivo obesity model can be used to further study the pathogenesis and pathophysiological processes of obesity and its related complications.
• Nutritional intervention research: The in vivo obesity model can be used to evaluate the effects of different dietary interventions on weight management, metabolic improvement, and health status.

Advantages

• We provide model customization services based on the specific needs of clients, such as adjusting dietary formulas, introducing specific environmental factors, etc., to more accurately simulate the obesity status of specific populations.
• Our in vivo obesity model highly simulates the physiological and pathological state of human obese patients, including gene expression, metabolic pathways, fat distribution, and complication development.
• We have a diverse library of in vivo obesity models, including genetically induced, diet-induced, hormone-regulated, and other types. These models cover the pathogenesis of different types of obesity, allowing us to explore the complexity and diversity of obesity from all aspects and angles.
• We actively establish cooperative relationships with top scientific research institutions, universities, and medical institutions around the world. We achieve optimal allocation and sharing of research resources through interdisciplinary cooperation and resource integration.

Publication

Our Services

Frequently Asked Questions

How do the in vivo obesity models provided by your company simulate the human obesity state?

We use carefully designed experimental protocols, genetic engineering, special diet formulations, or drug induction to simulate physiological and pathological characteristics similar to human obesity in animal models. These models reflect key aspects such as obesity-related metabolic changes, fat accumulation patterns, insulin resistance, and inflammatory responses, thus providing powerful tools for studying the pathogenesis of obesity and its complications.

What types of in vivo obesity models does your company have? How to choose the right model?

We provide a variety of in vivo obesity models, including but not limited to genetic obesity models (such as ob/ob mice), diet-induced obesity models (such as rats or mice fed a high-fat diet), and specific gene knock-out or transgenic models. Choosing the right model depends on the specific purpose of the study, the type of obesity to be simulated, and the research budget and time. Our professional team provides personalized model selection recommendations based on client needs and research background.

At Protheragen, our commitment is to ensure that you receive the tailored and scientifically robust in vivo obesity models to advance your obesity research. Researchers can gain invaluable insights into the pathophysiology of obesity and evaluate potential therapeutic interventions with the utmost precision and reliability by utilizing our in vivo obesity models. Please feel free to contact us for more details if you are interested in our in vivo obesity models for obesity research!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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