Overview of Hypothalamic Injury-based In Vivo Obesity Model Development

Protheragen is committed to providing cutting-edge and precise scientific research services to global pharmaceutical research and development institutions. In the field of obesity research, we provide Preclinical Studies of Anti-Obesity Therapeutics. The construction of Obesity Models and the development of In Vivo Obesity Models for Obesity Research are key links. Therefore, we are proud to launch the hypothalamic injury-based in vivo obesity model development service, which aims to provide highly customized animal models for preclinical research of anti-obesity drugs by simulating the pathological process of obesity caused by hypothalamic injury.

We specialize in the hypothalamic injury-based in vivo obesity model development service to propel Anti-Obesity Therapy Development. By inducing precise hypothalamic injuries that mimic the neural disruptions observed in obesity-related conditions, our models offer a realistic environment to assess the therapeutic impact of our candidate treatments.

Pioneering Hypothalamic Injury-based In Vivo Obesity Models to Revolutionize Research and Deliver Groundbreaking Therapeutic Solutions

The principle of developing an obesity model with hypothalamic injury is to simulate damage to key areas of the hypothalamus, especially the ventromedial nucleus. These areas play a core role in regulating appetite, energy balance, and weight management. Normal feeding and metabolic regulation mechanisms may be disrupted by artificially causing damage to these areas and leading to obesity-related symptoms such as increased appetite and reduced energy consumption in animals. An animal model close to the pathological process of human obesity is constructed, which is used to study the pathogenesis of obesity and evaluate the efficacy of anti-obesity drugs.

• Animal Selection and Preparation

  Adult rodents such as rats or mice with matching age, weight, and sex are selected to ensure the consistency and repeatability of the experiment.

  The animals are adaptively raised to ensure that they are in a healthy and stable state before the experiment.

• Construction of Hypothalamic Injury Model

  Specific areas of the hypothalamus of animals are precisely injured using sophisticated neurosurgical techniques. Injury methods include electrolysis, laser or chemical ablation, etc., and the specific methods are customized according to experimental needs.

  The recovery of the animals is closely monitored after surgery to ensure the stability and consistency of the injury site.

• Obesity Phenotype Induction and Monitoring

  The animals are given a high-fat diet to promote the rapid development of the obese phenotype.

  Key indicators such as weight, body fat percentage, food intake, and energy consumption of the animals are regularly monitored to evaluate the effectiveness of the model.

• Physiological and Metabolic Assessment

  Blood biochemical analysis is performed to detect changes in metabolic-related indicators such as insulin, glucose, and triglycerides.

  Dual-energy X-ray absorptiometry (DEXA) is used to assess total body fat content and distribution.

  Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) are performed to assess peripheral and central insulin sensitivity.

Workflow

We start by communicating with clients to clarify their research needs and design tailored experimental plans. We then prepare animals and perform precise hypothalamic surgeries to simulate obesity. Post-surgery, we ensure smooth recovery, introduce a high-fat diet, and monitor key indicators. We conduct biochemical tests and insulin sensitivity assessments to understand the animals' physiological status. After the experiment, we analyze data and compile detailed reports, providing follow-up support and consulting services to clients for deeper research insights.

Applications of Hypothalamic Injury-based In Vivo Obesity Model

• Drug development and testing: This model provides an ideal testing platform for the development of new drugs for hypothalamic injury-related obesity.
• Pathological mechanism research: Through this model, scientists deeply study the specific mechanism of how hypothalamic injury leads to obesity, including neuroendocrine regulation imbalance and energy metabolism abnormalities.
• Personalized medical plan formulation: This model helps professionals more accurately assess the degree of hypothalamic injury in different patients and its impact on obesity.

Advantages

• We provide animal models of different species, genders, and ages according to client needs.
• We provide customized injury plans, including injury site, degree, and method.
• We provide flexible monitoring cycles and indicator selection to meet the needs of different research stages.

Publication

Our Services

Frequently Asked Questions

Why is the hypothalamus injury model important for studying obesity?

The hypothalamus is a key center for regulating energy balance, appetite, and metabolism. We better understand the neuroendocrine mechanism of obesity and provide an important basis for the development of new anti-obesity drugs and treatment strategies by simulating hypothalamic injury. The hypothalamic injury model is highly physiologically relevant and can more accurately reflect the pathological process of human obesity.

Why choose your company's hypothalamic injury obesity model service?

Our company has rich experience and expertise in this field, with advanced experimental technology and a team of senior scientists and technicians. We provide high-quality, personalized services to meet the research needs of different clients. In addition, we focus on communication and cooperation with clients to ensure the pertinence and practicality of experimental plans.

Protheragen is committed to providing cutting-edge biotechnology services. Our hypothalamic injury-based in vivo obesity model development service provides the scientific research community with a highly customized obesity animal model by accurately simulating the obesity pathological process caused by hypothalamic injury. Please feel free to contact us for more details if you are interested in our hypothalamic injury-based in vivo obesity model development service!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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