Overview of Mammal Obesity Model

Obesity, which is caused by factors such as genetics or nutritional supply and results in excessive energy in the form of fat in the body, poses a great threat to human health. Many factors affect the body produce obesity, such as genetic factors, nutritional factors, developmental stage, gender, etc. Protheragen has established different In Vivo Obesity Models for different aspects to improve the reliability of the results. These models not only help us to unravel the complexity of obesity but also are a key tool to promote anti-obesity preclinical research.

Mammal Obesity Model Holds Exponential Possibilities

• Mammal Obesity Modeling

  Model selection: In selecting mammals, our researchers take into full consideration the purpose of the experiment, experimental conditions, animal strain, sex, age, feed formulation, etc., to provide the best solution for clients.

  Model construction: Our company provides a variety of modeling services such as dietary induction, chemical induction, gene editing, and drug injection.

  Model evaluation: We have a team of analysts who continue to analyze the animal model to evaluate the model. For example, our researchers assess the effect of a high-fat diet on obesity in animals by comparing body weight, body fat percentage, and blood lipid levels in normal control and high-fat model groups.

• Our Advanced Mammal Obesity Model

  Protheragen provides these mammalian obesity models. If you are interested in other animal models, our professional modeling team provides custom animal model development services for clients.

  Dog Obesity Model

  Our company provides high-quality dog obesity models for the study of obesity and other metabolic diseases. Our professional biology team has extensive experience in animal induction modeling and metabolic evaluation.

  Pig Obesity Model

  According to the different research needs of clients, we provide different types of pig obesity models such as diet-induced obesity model, genetic obesity model, and gene-edited obesity model.

  Mouse Obesity Model

  Our company provides not only conventional obese mouse models but also gene-edited obese mouse. It is important to make sure whether it is a simple obesity model or not.

  Rat Obesity Model

  Through scientific and reasonable experimental design and strict experimental operation, our researchers help clients construct stable and reliable rat obesity models.

  Monkey Obesity Model

  Monkey obesity models are highly similar to humans in terms of genetics, physiology, and metabolism, and thus more accurately mimic the pathophysiological processes of human obesity and its related diseases.

  Guinea Pig Obesity Model

  Guinea pigs have certain special characteristics. Based on a team of professional talents, our company provides high-quality guinea pig obesity model construction services.

  Rabbit Obesity Model

  Our professional researchers provide rabbit obesity model construction services. According to the different research needs of clients, we provide a variety of induction modeling services.

Workflow

The construction of the mammalian obesity model mainly includes the selection of suitable experimental animals, the design of an induction program, regular monitoring of body weight, and evaluation of obesity-related indicators. Meanwhile, our researchers pay more attention to feed transition, nutritional balance, individual differences, and ethical review to ensure the accuracy and reliability of the model construction.

Applications

• The mammal obesity model can be used to study the effects of pharmacological interventions.
• The mammal obesity model can be used to study the pathogenesis of obesity and its related diseases, such as insulin resistance and abnormalities of fat metabolism.
• The mammal obesity model can be used to evaluate the efficacy and safety of new drugs and provide new drug options for the treatment of obesity and its related diseases.
• The mammal obesity model can be used to study the effects of different nutrients on obesity and its related diseases.

Advantages of Us

• Our researchers strictly control feed composition and intake to ensure the stability and reliability of the model.
• Our company provides a clean, quiet, and comfortable environment at all times to minimize stressful stimuli for the animals.
• Our researchers take into account the specific characteristics of each species in the design of our programs to ensure the best possible service.

Your Best Assistant in Anti-Obesity Research

Our company has accumulated many years in the field of obesity and is committed to providing unique solutions to our clients. We have advanced technology and experienced researchers in target discovery and therapeutic testing. No matter what questions you may have about your anti-obesity research, our staff is always available to serve you with a warm and professional attitude.

Our Services

Our company is committed to providing highly effective anti-obesity solutions to our clients worldwide. Using cutting-edge algorithms and genetic data, our researchers delve into the genes and biomarkers associated with obesity to accurately predict obesity. Moreover, our researchers uncover the in vivo mysteries of obesity through microbiome and pathology studies.

Publication Data

Frequently Asked Questions

What are the indicators of animal model evaluation?

• General observations: General observation refers to the observation of body mass, amount of water intake, mental status, dorsal hair color, and amount of feces of the experimental animals during the modeling period.
• Observation of morphological indicators: Morphological indicators mainly include the observation of body mass changes, the relative mass of internal organs, and the determination of associated fat.
• Functional and histopathologic observations of the liver: The liver is an important organ for human metabolism. Obesity tends to affect liver function and change the morphology of liver cells. We mainly provide liver function and hepatocyte testing.
• Energy metabolism observations: Metabolic data generally include respiratory exchange efficiency (ratio of CO₂ release to O₂ consumption), spontaneous activity, and heat production (energy metabolism per unit of body mass per hour).
• Serum-related biochemical indicators: Obesity leads to abnormalities in blood lipid metabolism. Serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), are commonly used indicators to study abnormalities in blood lipid metabolism.

What are the factors affecting modeling?

The main factors affecting modeling include animal species, diet formulation, obesity resistance, age, and sex.

The mammalian obesity models Protheragen provides are used as an excellent tool for in-depth studies of metabolic diseases. Our company is committed to solving all the problems encountered by our clients in preclinical studies of anti-obesity. Whatever your questions, feel free to contact us!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Chemical-induced Obesity Model
• Custom Chromosome Replacement Model Service
• Custom Multi-Gene Mutation Model Service
• Custom Single Gene Editing Model Service
• Custom Single Gene Mutation Model Service
• Custom Transgenic Model Service
• Drug Injection-based In Vivo Obesity Model Development Service
• Gene Editing-based In Vivo Obesity Model Development Service
• High Fat-induced Obesity Model
• High Sugar-induced Obesity Model
• Hypothalamic Injury-based In Vivo Obesity Model Development Service
• Non-mammal Obesity Model
• Oophorectomy-based In Vivo Obesity Model Development Service
• Other Nutrient-induced Obesity Model
• Protein-induced Obesity Model