Overview

To comprehensively analyze the physiological and pathological processes of obesity, Protheragen provides professional Preclinical Studies of Anti-Obesity Therapeutics. We offer a wide range of Obesity Models depending on the different research needs of our clients. The fact that different species share certain similarities at the molecular, cellular, tissue, organ, and individual levels means that the results of animal experiments may shed some light on the mysteries of the human body.

Pig Model: Exploring Ideal Biological Models in Obesity Research

• Pig Obesity Modeling

  High-fat, high-sugar induced model: Our researchers use a high-fat, high-sugar diet and restricted animal activity (single-cage housing) to induce obesity.

  Genetic obesity model: Our company has abundant animal resources. Some of the breed lines that are prone to develop obesity can be used directly as models for genetic obesity, such as the Ossabaw pig, the Iberian pig, the Ningxiang pig, the obese Göttingen minipigs, etc.

  Gene-edited model: Based on the advantages of minipigs and the important impact of the leptin gene on obesity and related diseases, our lab utilizes gene editing technology to construct leptin gene knockout minipig obesity models.

• Appraisal and Validation

  For constructed models, we offer professional evaluation services such as body weight and body shape coefficient analysis, fat content and distribution determination (subcutaneous adipose tissue, retroperitoneal adipose tissue, and visceral adipose tissue), and serum indices detection.

  Our company provides advanced gut microbial and obesity analysis, biomarker identification, and whole genome sequencing services.

Workflow

Our company provides clients with one-stop solutions from experimental program design, and model construction to analytical data processing. The process of constructing a porcine obesity model usually involves selecting a suitable pig breed and designing a specific modeling scheme.

Depending on the client's research needs, we offer optimal induction programs. During the experimental period, our researchers regularly monitor body weight, fat content, and blood biochemical indicators (e.g., insulin, total cholesterol, triglycerides, etc.) to assess the effects of fat distribution and metabolism in pigs.

Ultimately, the mechanism of obesity and its impact on related metabolic diseases will be analyzed by comparing the differences between experimental and control groups. For the constructed porcine obesity model, we provide preclinical anti-obesity therapy testing to assess its safety and toxicity.

Applications

• The pig obesity model can be used to study the mechanisms of energy intake, storage, and utilization, and the effects of obesity on the metabolic system.
• The pig obesity model can be used to screen drugs or nutraceuticals with weight loss effects and evaluate their safety and efficacy.
• The pig obesity model can be used to study the relationship between obesity and metabolic diseases such as cardiovascular disease, diabetes mellitus, hypertension, and its pathogenesis.

Advantages of Us

• Our bio-researchers have many years of experience in metabolic disease modeling to provide our clients with the most satisfactory pig obesity modeling solutions.
• For analyzing and filtering large amounts of data, our company has a professional data analysis team to solve all problems for you.
• Our company supports both general and specialized testing services to meet the research needs of different clients.

Breaking the Obesity Cycle: Cutting Edge Research and Strategies

In the field of anti-obesity research, our company is committed to providing clients with a full range of services from target screening, therapeutic development to preclinical research, based on our deep expertise and practical experience. Our team consists of a group of experienced scientists and researchers with excellent professional backgrounds in obesity pathogenesis, drug development and metabolic research. We are committed to helping you achieve breakthroughs in anti-obesity research through our specialized research methodologies and advanced technological tools.

Our Services

Publication Data

Frequently Asked Questions

What are the advantages of choosing pigs as an animal model of obesity?

• Metabolic similarity: Pigs possess extremely similar metabolic characteristics, cardiovascular system, and proportionally sized organs to humans.
• Adipose tissue characteristics: Pigs do not continue to produce brown fat after birth and have more adipose tissue. It facilitates multiple assays for adipocytes or stromal vascular cells.
• Genetic engineering: The genome sequence of the pig is clear, which makes it easy to be modified by genetic engineering tools.

How do diet-induced obesity models change from normally reared pigs?

Obese animals generally exhibit increased body weight, increased body fat ratio, and decreased muscle ratio compared to conventionally fed animals. Moreover, serum total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels are increased, with mild elevation of fasting glucose and mild elevation of insulin compensation, and mild abnormalities of glucose tolerance.

Based on a highly efficient biology team, Protheragen provides reliable porcine obesity models for obesity studies. Please feel free to contact us for any reason whatsoever.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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