Overview of Energy Expenditure Monitoring

An imbalance between energy intake and energy expenditure leads to excessive accumulation of Body Fat. We aim to evaluate the energy metabolism effects of novel anti-obesity therapies in Animal Models through precise and efficient experimental means. Protheragen utilizes an advanced indirect calorimetry system, combined with sophisticated physiological monitoring technology, to non-invasively monitor key parameters such as energy expenditure, respiration, and activity level of experimental animals in different physiological states around the clock. Our lab provides clients with comprehensive and in-depth data support and accelerates the process of preclinical anti-obesity study development.

Your Most Reliable Partner for Energy Expenditure Monitoring

Protheragen utilizes an automated comprehensive laboratory animal monitoring system (CLAMS) to provide a variety of energy expenditure monitoring including but not limited to basal energy expenditure, resting energy expenditure, activity energy expenditure, diet-induced thermogenesis (DIT), and daily energy expenditure. We use indirect calorimetry (IC) to test the difference between basal energy expenditure and resting energy expenditure.

• Eating Behavior and Energy Expenditure

  According to our client's needs, we perform real-time assays on treated animal models. We calculate DIT by controlling dietary and water intake such as number of meals, meal size, cumulative food intake, meal duration, postprandial interval, and feeding rate.

  Our company evaluates energy expenditure by measuring oxygen consumption and carbon dioxide production.

• Fecal Energy Density

  Our staff collects feces and dries them at 60°C for 72 hours. Our researchers determine energy density by adiabatic bomb calorimeter.

Workflow

Relying on our professional pharmacology team, we provide our clients with very reliable animal models for energy expenditure monitoring. Based on the client's needs and target specificity, our researchers provide professional animal disease model development services. Based on CLAMS, we provide clients with uninterrupted observation services. Our lab provides professional data analysis services to help clients quickly elucidate mechanisms.

Applications

• Energy expenditure monitoring can be used to explore in depth the mechanisms of energy metabolic homeostasis in the development of obesity.
• Energy expenditure monitoring can be used for screening anti-obesity drug candidates.
• Energy expenditure monitoring can be used for the optimization of the administered dose of anti-obesity therapies.
• Energy expenditure monitoring provides a new way to analyze metabolic disease mechanisms.

Advantages of Us

• Our monitoring system is capable of monitoring multiple channels simultaneously, which greatly reduces the project cycle time and allows for a large amount of data to be collected in a short time.
• Our company uses high-precision sensors to measure the animal's diet, water intake exercise level, etc., to ensure the accuracy of the measurement results.
• Our highly efficient data analysis team uses automated data process software to reduce manual errors and biases and improve data reliability.

While obesity research shows great potential for exploring innovative therapies and improving health, its multidimensional and complex physiological mechanisms present inherent challenges to research efforts. At Protheragen, we specialize in obesity research and have developed deep expertise in understanding the complex causes of obesity and effective intervention strategies. We are well-versed in the multidimensional research processes associated with obesity, from genetic factors to environmental factors to metabolic mechanisms. We provide cutting-edge analyses and solutions for obesity research and its related interventions.

Our Services

Publication Data

Frequently Asked Questions

What modules are included in the energy monitoring system?

The energy monitoring system is an ingenious blend of diverse functional modules that are seamlessly integrated and synergized through unified management software. Functional modules include, but are not limited to: an ambient temperature control module, autonomous activity and training module, respiration and entropy metabolism monitoring module, physiological telemetry monitoring module, diet and weight monitoring module, learning and memory monitoring module, and urine/feces monitoring module.

What are the considerations for choosing an animal model?

To ensure the clinical relevance of the findings, the animal model must possess sufficient similarities to humans.

• Disease homology (similar pathogenesis to human disease)
• Phenotypic homology (similar behavioral phenotypes to human disease)
• Drug predictability (similar response to drug therapy to human disease)

Protheragen provides the most accurate energy expenditure monitoring services to clients worldwide. Our researchers have extensive experience in preclinical studies of anti-obesity therapies. Whatever your confusion, please feel free to contact us to answer your questions!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Food/Water Intake Assessment
• Measurement of Ectopic Fat Accumulation
• Molecular Biomarker Analysis
• Quantitative Analysis of Body Fat Distribution