Guinea Pig Obesity Model

Inquiry

Overview of Guinea Pig Obesity Model

At Protheragen, we recognize the growing necessity of innovative and reliable animal models for Preclinical Studies of Anti-Obesity Therapeutics. The guinea pig obesity model stands out due to its physiological similarities to human adiposity development during fetal stages. We provide comprehensive services that include various Obesity Models especially In Vivo Obesity Models for Obesity Research. Our goal is to not only facilitate advanced research but to offer customizable solutions that meet the specific needs of our clients.

We harness the guinea pig obesity model as a pivotal asset in evaluating and advancing Anti-Obesity Therapy Development. This model, characterized by its metabolic similarities to humans, provides a robust platform for assessing the potential of Anti-Obesity Small Molecule Drug Development and Anti-Obesity Nanotherapy Development. By mimicking human obesity-associated pathophysiology, it allows us to gain comprehensive insights into the therapeutic mechanisms and outcomes.

Advance Obesity Research with Our Specialized Guinea Pig Models

The guinea pig obese model has a unique advantage because guinea pigs have the inherent characteristics of accumulating fat in the palace stage similar to the development of human obesity. We use several types of guinea pigs such as Dunkin-Hartley to build this model effectively.

Selection of Guinea Pigs

We primarily utilize breed strains known for their metabolic profiles resembling those of humans. These include specific inbred strains that exhibit consistent and reproducible obesity phenotypes.
Model Construction

Dietary Induction: One primary technique involves subjecting pregnant guinea pigs to a high-fat diet. This approach ensures that the offspring are born with varying degrees of adiposity, closely mimicking human obesity development from the intrauterine stage.

Postnatal Dietary Modification: After birth, the offspring are subjected to controlled high-fat dietary regimes to evaluate ongoing adiposity development and metabolic responses.
Evaluation

Body Composition Analysis: We utilize sophisticated imaging techniques such as dual-energy X-ray absorptiometry (DEXA) to assess fat distribution and bone density.

Metabolic Assessments: We conduct glucose tolerance tests, insulin sensitivity assessments, and other metabolic profiling to gauge the impact of dietary interventions.

Workflow

Schematic diagram of guinea pig obesity model construction. (Protheragen)

Applications of Guinea Pig Obesity Model

Disease mechanism research: The guinea pig obesity model can be used to explore the specific mechanism between certain chronic diseases and obesity.
Gene function research: The role of specific genes in obesity and related diseases can be studied by constructing a genetically modified guinea pig obesity model.
Environmental factor impact assessment: The guinea pig obesity model can be used to evaluate the impact of environmental factors (such as stress, light, temperature, etc.) on the development of obesity.

Advantages

Professional team and rich experience: We have a professional team of senior scientists and engineers who have many years of research experience in the construction of guinea pig obesity models.
Comprehensive technical support: We provide a full range of technical support from experimental design to data analysis.
Efficient cooperation process: We focus on communication and cooperation with clients to ensure the smooth progress of the project. We provide clear cooperation processes and project management tools to enable clients to understand project progress and results in real-time.

Publication

Technology: Establishment and evaluation of an obese guinea pig model

Published: 2019

Journal: Arthritis Research & Therapy

IF: 1.59

Results: The authors explore the establishment and evaluation of an obese guinea pig model. To induce obesity, 6- to 7-week-old male Dunkin-Hartley guinea pigs were divided into four groups: ad libitum regular chow (obese), calorie-restricted regular chow (lean), ad libitum high-fat diet (HFD), and calorie-restricted HFD. The regular chow diet was high in protein (31%) and carbohydrates (57%), with moderate fat (12%), while the HFD provided 30% calories from fat and less protein (18%). Evaluation of the model involved measuring body weight, tibial length, masseter muscle width, and weights of epididymal fat pads and infrapatellar fat pads. Complete blood counts and serum biochemical analyses were used to evaluate systemic metabolic changes associated with obesity.

Fig.1 Total body weight (a) and tibial length (b) in obese, lean, and HFD groups. (Radakovich, et al., 2019)

Our Services

Obesity Pathobiology Research Service

Our obesity pathobiology research service builds upon this model, offering comprehensive analyses that delve into the intricate pathobiology of obesity. This service encompasses the Obesity Signaling Pathway Functional Analysis Service, which investigates the signaling cascades that regulate energy balance, fat accumulation, and metabolic homeostasis. We identify potential therapeutic targets for obesity management by analyzing these pathways. Furthermore, obesity pathobiology also encompasses the Obesity Physiology and Biochemistry Analysis Service, which examines the physiological and biochemical changes associated with obesity.

Frequently Asked Questions

Why choose the guinea pig obesity model instead of other animal models?

Guinea pigs are widely used in obesity research due to their similarities with humans in metabolism, fat distribution, and gene expression. They are sensitive to dietary changes, easy to induce obese phenotypes, and the model is stable and reliable. They are ideal for evaluating the effects of anti-obesity drugs and studying the mechanisms of obesity-related diseases.

How can your company support us if we encounter problems or challenges during the service process?

We provide a full range of technical support and service guarantees. During the service process, if you encounter any problems or challenges, our professional team will respond quickly and provide solutions. We also provide regular progress reports and discussion meetings to ensure that both parties maintain full communication and understanding of project progress and possible problems.

Protheragen focuses on providing high-quality guinea pig obesity model development services. We provide reliable and stable model solutions for drug development, nutrition research, disease mechanism exploration, and other fields through precise experimental design and strict quality control, helping clients achieve breakthroughs in obesity-related research. Please feel free to contact us for more details if you are interested in our guinea pig obesity model development services!

Reference

Radakovich, L.B.; et al. Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model. Arthritis research & therapy. 2019, 21: 1-14.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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