Overview of High Sugar-induced Obesity Model

Among the current global health challenges, obesity and its related metabolic diseases such as type 2 diabetes have become major public health issues. Protheragen, as a leader in the field of biotechnology, is committed to providing cutting-edge scientific research solutions to meet these challenges. We specially launch the high sugar-induced obesity model service. As an important part of our Preclinical Studies of Anti-Obesity Therapeutics, this model not only enriches the content of our Obesity Models but is also an innovative work in the field of In Vivo Obesity Models for Obesity Research.

We leverage our high sugar-induced obesity model to significantly accelerate Anti-Obesity Therapy Development. This model closely mimics human obesity conditions, providing a robust platform to evaluate the efficacy and safety of potential treatments. By simulating the metabolic disturbances caused by a high-sugar diet, we precisely identify compounds that target obesity-related pathways, thereby facilitating the discovery of innovative therapeutic solutions.

Innovative Solutions for High Sugar-Induced Obesity Model Development: Pioneering Research for Better Health and Effective Treatments

Long-term intake of high-sugar foods leads to a continuous increase in blood glucose levels and stimulates the secretion of insulin to promote glucose into cells and convert it into fat storage. When this process occurs repeatedly, body fat accumulation increases and energy consumption is relatively insufficient, eventually leading to weight gain and obesity.

• Model Animal Selection

  In the construction of a high sugar-induced obesity model, we prefer experimental animals that have a high similarity to the human metabolic system to ensure the high translatability of experimental results. These animal models are not only easy to raise but also sensitive to metabolic changes induced by a high-sugar diet.

• High Sugar Diet Induction

  Our carefully formulated high-sugar diet simulates the scenario of excessive intake of sugary foods in humans. The diet typically contains high concentrations of sucrose, fructose, or other monosaccharide and disaccharide mixtures, while ensuring that the basic nutrients required by animals, like protein, fat, vitamins, and minerals, meet nutritional standards to avoid interference caused by nutritional deficiencies.

• Model Construction

  Baseline data collection: Before administering the high-sugar diet, the experimental animals undergo baseline data measurements, including body weight, body fat percentage, blood sugar, and blood lipids, to ensure no significant differences between groups.

  High-sugar diet feeding: The experimental animals are randomly divided into a high-sugar diet group and a control group. They are fed a customized high-sugar diet and a standard diet respectively as determined by the experimental design.

  Regular monitoring: Throughout the feeding period, the body weight, body fat percentage, food intake, water intake, and other physiological indicators of animals are regularly measured and recorded. Blood samples are also collected for analysis of biochemical indicators like blood sugar, insulin, and blood lipids.

  Tissue sample collection: At the conclusion of the experiment, the primary metabolic organs of the animals (e.g., liver, adipose tissue, pancreas) are collected for in-depth analysis, including histology and molecular biology.

• Model Evaluation

  Changes in body weight and body fat percentage: Evaluate the effect of the high-sugar diet on animal weight and body fat percentage as a direct indicator of the success of the obesity model.

  Biochemical index analysis: This method assesses the impact of the high-sugar diet on the metabolic state of animals through the detection of biochemical indicators such as blood sugar, insulin, and blood lipids.

  Histopathological examination: Further observation of morphological changes in metabolism-related organs like the liver and adipose tissue confirms the occurrence of obesity and related metabolic abnormalities.

Workflow

We initiate obesity research projects by consulting with clients to define experimental needs and outline a comprehensive plan. We procure and raise suitable animals, gather baseline data, and then implement dietary interventions with a controlled group. Regular monitoring of body weight, fat percentage, and biochemical indicators ensures precise data collection. Post-experiment, we gather tissue samples for histological and molecular analysis. Experimental data is meticulously organized into a detailed report, encompassing methods, results, discussions, and conclusions. Finally, we present the report and data to clients, engaging in follow-up communication and services tailored to their feedback.

Applications of High Sugar-induced Obesity Model

• Mechanism research: This model can be used to study the specific molecular mechanisms of high-sugar diet-induced obesity, including insulin resistance, adipocyte differentiation, and metabolic pathways.
• Nutritional intervention research: This model can be used to explore the prevention and reversal effects of different dietary intervention measures on high-sugar-induced obesity.
• Metabolic syndrome research: This model can be used to correlate and analyze the relationship between high-sugar diet-induced obesity and other metabolic syndromes, providing a basis for comprehensive treatment.

Advantages

• Professional team: We have a team of senior scientists and professional technicians to ensure the scientificity and accuracy of model construction.
• Advanced technology: We use the latest biotechnology and experimental methods to ensure the efficiency and stability of the model to meet different research needs.
• Personalized customization: We provide one-to-one client service and tailor the high-sugar-induced obesity model program according to client needs to ensure the targeted research.

Publication

Our Services

Frequently Asked Questions

What follow-up support does your company provide after the model is built?

After the model is built, we provide a detailed experimental report, including key data such as weight changes, blood sugar levels, and insulin sensitivity of animals. In addition, our professional team also provides follow-up support services such as data analysis, paper writing, and publication guidance according to your needs. We are committed to helping you make full use of model data to promote the output and transformation of research results.

What if I have questions or need to adjust a certain link in the model construction process?

Our service price is determined based on factors such as the complexity of the model, experimental cycle, sample size, and required technical support. We are committed to providing cost-effective services to ensure that clients can control research costs while obtaining high-quality models. For long-term cooperative clients or clients who place bulk orders, we provide preferential policies based on actual conditions. Please consult our sales staff for details.

Protheragen focuses on providing high sugar-induced obesity model development services. We use advanced biotechnology to simulate long-term high-sugar diet habits and precisely regulate sugar metabolism and fat accumulation in experimental animals. We build efficient and stable obesity models for clients and facilitate drug development for obesity and related diseases. Please feel free to contact us for more details if you are interested in our high sugar-induced obesity model development services!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Chemical-induced Obesity Model
• Custom Chromosome Replacement Model Service
• Custom Multi-Gene Mutation Model Service
• Custom Single Gene Editing Model Service
• Custom Single Gene Mutation Model Service
• Custom Transgenic Model Service
• Drug Injection-based In Vivo Obesity Model Development Service
• Gene Editing-based In Vivo Obesity Model Development Service
• High Fat-induced Obesity Model
• Hypothalamic Injury-based In Vivo Obesity Model Development Service
• Mammal Obesity Model
• Non-mammal Obesity Model
• Oophorectomy-based In Vivo Obesity Model Development Service
• Other Nutrient-induced Obesity Model
• Protein-induced Obesity Model