Overview of Oophorectomy-based In Vivo Obesity Model Development

At Protheragen, we are committed to promoting innovation and development in the field of life sciences, especially in the research of obesity and related diseases. As an important part of our Preclinical Studies of Anti-Obesity Therapeutics, we are proud to launch the oophorectomy-based in vivo obesity model development service. This service is based on a deep understanding of the pathophysiological mechanisms of obesity, especially the complex effects of ovarian hormones on energy metabolism and body weight regulation. By combining our rich experience in Obesity Models, especially In Vivo Obesity Models for Obesity Research, we provide clients with highly customized model development services to support the early development of obesity and its therapeutic drugs.

We offer an innovative oophorectomy-based in vivo obesity model development service to facilitate Anti-Obesity Therapy Development. By simulating the hormonal changes associated with oophorectomy, which is the surgical removal of ovaries, our models recreate the post-menopausal obesity scenario prevalent in many women. These models provide a unique platform to evaluate the efficacy of our anti-obesity therapy candidates, assessing their ability to regulate body weight, improve insulin sensitivity, and modify fat distribution.

Rely on Our Specialized Oophorectomy-based In Vivo Models for Unrivaled Obesity Research and Therapeutic Development

The ovaries are important endocrine organs in women. While maintaining women's reproductive health, they are also involved in regulating energy metabolism and weight balance. These hormones have a profound impact on body weight and metabolic status by affecting the distribution of adipose tissue, appetite regulation, energy expenditure, and insulin sensitivity. Ovariectomy may lead to changes in fat distribution, increased appetite, reduced energy expenditure, and decreased insulin sensitivity.

• Model Construction

  Animal selection and preparation: We select experimental animals (such as mice or rats) with a clear genetic background and stable physiological state to ensure the reliability and repeatability of experimental results. Before surgery, the animals are given detailed health checks and weight records to ensure that they meet the experimental requirements.

  Ovariectomy: Ovariectomy is performed under sterile conditions by experienced veterinarians or researchers. During the operation, we strictly follow the principles of aseptic operation to reduce surgical trauma and postoperative complications. After the operation, the animals are closely observed and cared for to ensure their smooth recovery.

  Postoperative recovery and monitoring: After the operation, we conduct regular health checks and weight monitoring on the animals, and record key indicators such as weight changes, food intake, and activity levels. At the same time, we will also pay attention to changes in the hormone levels of the animals, especially the fluctuations of key hormones such as estrogen and androgen.

• Model Evaluation

  Obesity phenotype evaluation: We evaluate whether the model successfully simulates the obesity phenotype caused by ovarian hormone deficiency by comparing weight changes, body fat distribution, and metabolic parameters (such as blood sugar and blood lipids) before and after ovariectomy.

  Metabolic function evaluation: We use advanced equipment such as metabolic cages to monitor metabolic parameters such as energy consumption, respiratory quotient, and substrate utilization of animals in real time to further understand the impact of ovariectomy on energy metabolism.

  Drug efficacy evaluation: After the model is stable, we introduce candidate anti-obesity drugs into the model according to client needs, and evaluate the efficacy and safety of the drugs by comparing the weight changes of animals before and after treatment, the improvement of metabolic parameters, and other indicators.

  We provide highly customized services, including but not limited to animal species selection, surgical plan design, postoperative care plan adjustment, and optimization of drug efficacy evaluation indicators.

Workflow

We start with a consultation to understand client objectives and design a customized oophorectomy-based obesity model. We then prepare animals, collect baseline data, and perform the surgery with post-operative care. Post-surgery, we monitor animals for changes and implement therapeutic interventions. Collected data is analyzed to assess intervention impacts, and we generate detailed reports. Finally, we review outcomes with clients, optimizing the model for future studies.

Applications of Oophorectomy-based In Vivo Obesity Model

• Oophorectomy female animals can be used to simulate how estrogen deficiency affects weight management, metabolic processes, and obesity-related complications.
• The oophorectomy-based obesity model can be used to compare the effects of different weight loss strategies under estrogen deficiency and normal estrogen levels.
• The oophorectomy-based obesity model can be used to further explore the interaction mechanism between obesity, inflammation, and insulin resistance, and provide a theoretical basis for the development of anti-inflammatory weight loss strategies.

Advantages

• Highly customized solutions. We provide highly customized oophorectomy obesity model development services, which can be flexibly adjusted according to the specific needs of clients, from animal species selection, and surgical plan design to model evaluation indicators.
• Professional technical team. Our technical team is composed of experienced biologists, veterinarians, and data analysis experts, who have deep professional knowledge and rich practical experience.
• Comprehensive technical support and consulting. We provide clients with a full range of technical support and consulting services during the model development process.

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Frequently Asked Questions

What is an oophorectomy-based in vivo obesity model and why is it important?

An oophorectomy-based in vivo obesity model is an animal model that induces obesity by surgically removing the ovaries of female animals (such as mice or rats). Ovaries are the main source of estrogen, and their removal leads to changes in hormone levels, which in turn affect fat metabolism and energy balance, ultimately leading to weight gain and obesity. This model is important for studying the pathogenesis of postmenopausal obesity, estrogen-dependent obesity, and related metabolic diseases in women because it can simulate the metabolic changes of human women under specific physiological states.

How long does it usually take to develop a model?

The length of model development time depends on multiple factors, including animal species, surgical complexity, postoperative recovery time, and specific requirements of the experimental design. Generally speaking, the entire development time from animal selection, and surgical operation to model stability assessment may take weeks to months. We will develop a detailed timeline based on your specific needs and project urgency, and strive to ensure that high-quality models are delivered on time.

Oophorectomy-based in vivo obesity model is a powerful tool for obesity research, particularly in studying post-menopausal weight gain due to hormonal changes. Oophorectomy disrupts the original hormone balance, leading to a series of physiological changes, thereby simulating obesity phenotypes and metabolic abnormalities. This model provides strong support for the study of obesity and related diseases. Please feel free to contact us for more details if you are interested in our oophorectomy-based in vivo obesity model development service!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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